Influence of mouse apolipoprotein A-II on plasma lipoproteins in transgenic mice.
Catherine C. Hedrick,Lawrence W. Castellani,Craig H Warden,Donald L. Puppione,Aldons J. Lusis +4 more
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TL;DR: Transgenic mice overexpressing mouse apoA-II exhibited more than a 2-fold increase in HDL levels as well as about a 25% increase in average HDL diameter, suggesting novel interactions among the classes of plasma lipoproteins.
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About: This article is published in Journal of Biological Chemistry. The article was published on 25 Sep 1993. and is currently open access. The article focuses on the topics: Apolipoprotein A-II & Apolipoprotein B.
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Citations
Molecular physiology of reverse cholesterol transport.
TL;DR: The removal of cholesterol from cells, like its delivery, appears to be specific and well regulated, and RCT can now be understood in molecular terms.
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Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures.
B J Van Lenten,Susan Hama,F C de Beer,Diana M. Stafforini,T M McIntyre,Stephen M. Prescott,B N La Du,A M Fogelman,Mohamad Navab +8 more
TL;DR: Under basal conditions HDL serves an anti-inflammatory role but during APR displacement and/or exchange of proteins associated with HDL results in a pro-inflammatory molecule.
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Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: step 1
Mohamad Navab,Susan Hama,Gattadahalli M. Anantharamaiah,Kholood Hassan,Greg Hough,Andrew D. Watson,Srinivasa T. Reddy,Alex Sevanian,Gregg C. Fonarow,Alan M. Fogelman +9 more
TL;DR: It is concluded that oxidation of LDL by artery wall cells requires seeding molecules that include HPODE and HPETE and normal HDL and its components can remove or inhibit the activity of lipids in freshly isolated LDL that are required for oxidation by human arteries wall cells.
675
Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis.
Diana M. Shih,Yu-Rong Xia,Xuping Wang,Elizabeth C. Miller,Lawrence W. Castellani,Ganesamoorthy Subbanagounder,Hilde Cheroutre,Kym F. Faull,Judith A. Berliner,Joseph L. Witztum,Aldons J. Lusis +10 more
TL;DR: It is demonstrated that PON1 deficiency promotes LDL oxidation and atherogenesis in apoE KO mice and that heme oxygenase-1, peroxisome proliferator-activated receptor γ, and oxidized LDL receptors were elevated in the livers of double KO mice as compared with the controls.
460
Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized low density lipoprotein.
Andrew D. Watson,M Navab,Susan Hama,Alex Sevanian,Stephen M. Prescott,Diana M. Stafforini,T M McIntyre,B N Du,A M Fogelman,Judith A. Berliner +9 more
TL;DR: It is suggested that PAF-AH in HDL protects against the production and activity of MM-LDL by facilitating hydrolysis of active oxidized phospholipid species to lysolipids, thereby destroying the biologically active lipids in MM- LDL.
References
Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.
TL;DR: Apolipoprotein E is a plasma protein that serves as a ligand for low density lipoprotein receptors and, through its interaction with these receptors, participates in the transport of cholesterol and other lipids among various cells of the body.
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Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions
TL;DR: With a single preparative ultracentrifugation, immunologically pure high density lipoproteins can be isolated from large volumes of serum.
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Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI.
TL;DR: To test the hypothesis that induction of a high plasma concentration of ApoA-I and HDL would inhibit this process of early atherogenesis, the effects of atherogenic diets on transgenic mice expressing high amounts of human Apo-I were studied.
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Characterization of lipoprotein particles isolated by immunoaffinity chromatography. Particles containing A-I and A-II and particles containing A-I but no A-II.
M C Cheung,John J. Albers +1 more
TL;DR: The variation in A-I/A-II ratio of HDL density subfractions therefore reflects different proportions of two discrete types of particles: particles containing A-i and A-II in a nearly constant ratio and particles containing C, D, and E, and LCAT (EC 2.3.43) in Lp (A-I with A- II) particles.
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