Journal Article10.1016/J.BBR.2008.09.032
Influence of environmental manipulation on exploratory behaviour in male BDNF knockout mice.
Shunwei Zhu,Alina Codita,Nenad Bogdanovic,Jens Hjerling-Leffler,Patrik Ernfors,Bengt Winblad,David W. Dickins,Abdul H. Mohammed +7 more
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TL;DR: The findings support the critical role of BDNF in behavioural and neural plasticity associated with environmental enrichment and suggest that besides maze learning performance, BDNF dependent mechanisms are also involved in other aspects of behaviour.
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About: This article is published in Behavioural Brain Research. The article was published on 11 Feb 2009. The article focuses on the topics: Brain-derived neurotrophic factor & Environmental enrichment.
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Citations
Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF
TL;DR: It is argued that while BDNF plays a role in exercise-induced cell proliferation, other factors must contribute to this phenomenon and that dendritic development was impaired in cKO mice maintained in standard housing conditions, and that EE rescued this phenotype.
Physical activity and environmental enrichment: Behavioural effects of exposure to different housing conditions in mice.
TL;DR: The data suggest that the complexity of the environment in which physical activity and environmental stimulation are provided can influence animal behaviours such as novelty seeking, emotional response, and pain sensitivity, which could be useful for designing more personalized interventions to promote a more active lifestyle in humans.
Limited effects of early life manipulations on sex-specific gene expression and behavior in adulthood.
E. Candemir,Antonia Post,Ulrich Dischinger,Rupert Palme,David A. Slattery,Aet O'Leary,Aet O'Leary,Andreas Reif +7 more
TL;DR: The long-term effects of maternal separation or environmental enrichment in male and female CD1 mice are investigated to find clear sex-specific effects, but limited influence of environmental manipulations, on adult behavior, corticosterone metabolite levels and stress- and plasticity related gene expression in discrete brain regions.
Environmental enrichment modulates intrinsic cellular excitability of hippocampal CA1 pyramidal cells in a housing duration and anatomical location-dependent manner.
TL;DR: The housing duration specificity observed here, together with previous findings, suggests that the modulation of some physiological properties by an environmental enrichment is transient, and could coherently account for earlier controversial reports.
Age-dependent deficits in fear learning in heterozygous BDNF knock-out mice.
Thomas Endres,Volkmar Lessmann +1 more
TL;DR: While reduced BDNF levels in general correlate with less efficient fear learning, this lack of BDNF can be compensated in young but not in older animals, suggesting that the cellular mechanisms responsible for fear learning consolidation become BDNF-dependent 3 mo after birth.
References
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Running enhances neurogenesis, learning, and long-term potentiation in mice
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TL;DR: High-density oligonucleotide microarray analysis has demonstrated that, in addition to increasing levels of BDNF, exercise mobilizes gene expression profiles that would be predicted to benefit brain plasticity processes, suggesting that exercise could provide a simple means to maintain brain function and promote brain Plasticity.
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Regulation of BDNF and trkB mRNA in Rat Brain by Chronic Electroconvulsive Seizure and Antidepressant Drug Treatments
TL;DR: The enhanced induction and prolonged expression of BDNF in response to chronic ECS and antidepressant drug treatments could promote neuronal survival, and protect neurons from the damaging effects of stress.
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TL;DR: The hypothesis that BDNF in the hippocampus produces an antidepressant effect in behavioral models of depression, the learned helplessness (LH) and forced swim test (FST) paradigms is tested and provides further support for the hypothesis thatBDNF contributes to the therapeutic action of antidepressant treatment.
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