Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment.
Sheng-Kai Hsu,Chia-Yang Li,I-Ling Lin,Wun-Jyun Syue,Yih Fung Chen,Kai-Chun Cheng,Yen-Ni Teng,Yi-Hsiung Lin,Chia-Hung Yen,Chien-Chih Chiu +9 more
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Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research
TL;DR: In this article , a review of the potential agents and nanoparticles that induce or inhibit RCD pathways and their therapeutic effects on cancer based on evidence from in vivo and in vitro studies and reports clinical trials in which RCD inducers have been evaluated as treatments for cancer patients.
Ferroptosis, necroptosis, and pyroptosis in the tumor microenvironment: perspectives for immunotherapy of SCLC.
TL;DR: In this paper , the authors summarize the roles of distinct ICD mechanisms on antitumor immunity and recent advances of ferroptosis-, necroptosis-and pyroptotic-inducing agents, and present perspectives on these cell death mechanisms in immunotherapy of small cell lung cancer.
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Neuronal cell death mechanisms in Alzheimer’s disease: An insight
TL;DR: This review attempts to elucidate the process of Regulatedcell death, how it gets unregulated in response to different intra and extracellular stressors, various forms of unregulated cell death, their interplay and their role in pathogenesis of Alzheimer’s Disease in both human and experimental models of AD.
Novel necroptosis-related gene signature for predicting the prognosis of pancreatic adenocarcinoma
TL;DR: NRGs and the relationship of the immune function, immune checkpoints, and m6A gene expression with NRGs in PAAD may be considered as potential therapeutic targets that should be further studied.
The deubiquitinase USP11 ameliorates intervertebral disc degeneration by regulating oxidative stress-induced ferroptosis via deubiquitinating and stabilizing Sirt3
TL;DR: In this article , USP11 was identified to stabilize Sirt3 via directly binding to Sirt 3 and deubiquitinating it, thus relieving intervertebral disc degeneration by increasing oxidative stress-induced ferroptosis.
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