Inflammation, fracture and bone repair
Florence Loi,Luis A. Córdova,Luis A. Córdova,Jukka Pajarinen,Tzuhua Lin,Zhenyu Yao,Stuart B. Goodman +6 more
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TL;DR: In this review, a comprehensive summary of the literature related to inflammation and bone repair is provided, placing special emphasis on the underlying cellular and molecular mechanisms, and potential interventions that can favorably modulate the outcome of clinical conditions that involve bone repair.
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About: This article is published in Bone. The article was published on 01 May 2016. and is currently open access. The article focuses on the topics: Bone remodeling & Osteolysis.
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Citations
Mesenchymal stem cell-macrophage crosstalk and bone healing
Jukka Pajarinen,Tzuhua Lin,Emmanuel Gibon,Yusuke Kohno,Masahiro Maruyama,Karthik Nathan,Laura Lu,Zhenyu Yao,Stuart B. Goodman +8 more
TL;DR: The current understanding of the interaction of Macrophages and MSCs during bone regeneration is summarized, with the emphasis on the role of macrophages in regulating bone formation and the potential implications of aging to this cellular cross-talk.
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Enthesitis: from pathophysiology to treatment
Georg Schett,Rik Lories,Maria Antonietta D'Agostino,Dirk Elewaut,Bruce Kirkham,Enrique R. Soriano,Dennis McGonagle +6 more
TL;DR: The role of biomechanics, prostaglandin E2-mediated vasodilation and the activation of innate immune cells in the initiation phase of enthesitis, as well as the role of entheseal IL-23-responsive cells that augment inflammation by producing pro-inflammatory mediators such as IL-17A, IL-22 and TNF are addressed.
402
Modulation of the Inflammatory Response and Bone Healing.
Masahiro Maruyama,Claire Rhee,Takeshi Utsunomiya,Ning Zhang,Masaya Ueno,Zhenyu Yao,Stuart B. Goodman +6 more
TL;DR: The principles of inflammation and bone healing are summarized, an update on cellular interactions and immunomodulation for optimal bone healing is provided and the resolution of inflammation with anti-inflammatory cytokines such as IL4, IL10, and IL13 is described.
Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds.
Guanyin Zhu,Tianxu Zhang,Miao Chen,Ke Yao,Xinqi Huang,Bo Zhang,Yazhen Li,Jun Liu,Yunbing Wang,Zhihe Zhao +9 more
TL;DR: In this article, the development of bone tissue engineering (BTE) scaffolds has been leading the forefront of this field, and various biomimicking and bio-inspired BTE scaffolds have been reported.
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The application of hyaluronic acid in bone regeneration
TL;DR: Local delivery carriers based on hyaluronic acid derivatives, rather than specifically serving as scaffolds, can be established by loading different osteoinductive or osteogenetic components and acquiring different release patterns to better enhance osteogenesis.
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Stephen M. Pirris,Eric W. Nottmeier,Sherri Kimes,Michael O'Brien,Michael O'Brien,Gazanfar Rahmathulla +5 more
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Inhibition of osteolysis and increase of bone formation after local administration of siRNA-targeting RANK in a polyethylene particle-induced osteolysis model.
Luis A. Córdova,Luis A. Córdova,Luis A. Córdova,Valérie Trichet,Virginie Escriou,Philippe Rosset,Jérôme Amiaud,Séverine Battaglia,Céline Charrier,Martine Berreur,Régis Brion,François Gouin,Pierre Layrolle,N Passuti,Dominique Heymann +14 more
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Osteoporotic Fracture Models
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Serum from children with polyarticular juvenile idiopathic arthritis (pJIA) inhibits differentiation, mineralization and may increase apoptosis of human osteoblasts “in vitro”
Valeria F. Caparbo,Flavia de Santis Prada,Clovis A. Silva,Paula L. Regio,Rosa Maria Rodrigues Pereira +4 more
TL;DR: It is suggested that serum from children with pJIA inhibits differentiation, mineralization and may increase apoptosis of hOb cultures, and inflammatory cytokines such as IL-6 might be a mechanism in this find.
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