Inflammation, fracture and bone repair
Florence Loi,Luis A. Córdova,Luis A. Córdova,Jukka Pajarinen,Tzuhua Lin,Zhenyu Yao,Stuart B. Goodman +6 more
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TL;DR: In this review, a comprehensive summary of the literature related to inflammation and bone repair is provided, placing special emphasis on the underlying cellular and molecular mechanisms, and potential interventions that can favorably modulate the outcome of clinical conditions that involve bone repair.
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About: This article is published in Bone. The article was published on 01 May 2016. and is currently open access. The article focuses on the topics: Bone remodeling & Osteolysis.
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Citations
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Modulation of the Inflammatory Response and Bone Healing.
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TL;DR: The principles of inflammation and bone healing are summarized, an update on cellular interactions and immunomodulation for optimal bone healing is provided and the resolution of inflammation with anti-inflammatory cytokines such as IL4, IL10, and IL13 is described.
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The application of hyaluronic acid in bone regeneration
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References
Chronic inflammation in biomaterial-induced periprosthetic osteolysis: NF-κB as a therapeutic target.
Tzuhua Lin,Yasunobu Tamaki,Jukka Pajarinen,Heather Waters,Deanna K. Woo,Zhenyu Yao,Stuart B. Goodman +6 more
TL;DR: Suppression of chronic inflammation via inhibition of NF-κB activity in patients with malfunctioning joint replacements may be an effective strategy to mitigate wear particle induced periprosthetic osteolysis.
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Impact of genomic damage and ageing on stem cell function
TL;DR: The impact of the various types of DNA damage that accumulate with ageing on stem cell functionality, as well as the development of cancer, is reviewed.
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Vegf incorporated into calcium phosphate ceramics promotes vascularisation and bone formation in vivo
Ellen Wernike,M.O. Montjovent,Y. Liu,Daniel Wismeijer,Ernst B. Hunziker,Klaus A. Siebenrock,Willy Hofstetter,Frank M. Klenke +7 more
TL;DR: In vivo, sustained delivery of VEGF achieved by protein co-precipitation promoted biomaterial vascularization, osseointegration, and bone formation demonstrating that a prolonged bioavailability of low concentrations of V EGF is beneficial for bone regeneration.
Osteal macrophages: a new twist on coupling during bone dynamics.
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