Inflammation, fracture and bone repair
Florence Loi,Luis A. Córdova,Luis A. Córdova,Jukka Pajarinen,Tzuhua Lin,Zhenyu Yao,Stuart B. Goodman +6 more
1K
TL;DR: In this review, a comprehensive summary of the literature related to inflammation and bone repair is provided, placing special emphasis on the underlying cellular and molecular mechanisms, and potential interventions that can favorably modulate the outcome of clinical conditions that involve bone repair.
read more
About: This article is published in Bone. The article was published on 01 May 2016. and is currently open access. The article focuses on the topics: Bone remodeling & Osteolysis.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Mesenchymal stem cell-macrophage crosstalk and bone healing
Jukka Pajarinen,Tzuhua Lin,Emmanuel Gibon,Yusuke Kohno,Masahiro Maruyama,Karthik Nathan,Laura Lu,Zhenyu Yao,Stuart B. Goodman +8 more
TL;DR: The current understanding of the interaction of Macrophages and MSCs during bone regeneration is summarized, with the emphasis on the role of macrophages in regulating bone formation and the potential implications of aging to this cellular cross-talk.
774
Enthesitis: from pathophysiology to treatment
Georg Schett,Rik Lories,Maria Antonietta D'Agostino,Dirk Elewaut,Bruce Kirkham,Enrique R. Soriano,Dennis McGonagle +6 more
TL;DR: The role of biomechanics, prostaglandin E2-mediated vasodilation and the activation of innate immune cells in the initiation phase of enthesitis, as well as the role of entheseal IL-23-responsive cells that augment inflammation by producing pro-inflammatory mediators such as IL-17A, IL-22 and TNF are addressed.
402
Modulation of the Inflammatory Response and Bone Healing.
Masahiro Maruyama,Claire Rhee,Takeshi Utsunomiya,Ning Zhang,Masaya Ueno,Zhenyu Yao,Stuart B. Goodman +6 more
TL;DR: The principles of inflammation and bone healing are summarized, an update on cellular interactions and immunomodulation for optimal bone healing is provided and the resolution of inflammation with anti-inflammatory cytokines such as IL4, IL10, and IL13 is described.
Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds.
Guanyin Zhu,Tianxu Zhang,Miao Chen,Ke Yao,Xinqi Huang,Bo Zhang,Yazhen Li,Jun Liu,Yunbing Wang,Zhihe Zhao +9 more
TL;DR: In this article, the development of bone tissue engineering (BTE) scaffolds has been leading the forefront of this field, and various biomimicking and bio-inspired BTE scaffolds have been reported.
322
The application of hyaluronic acid in bone regeneration
TL;DR: Local delivery carriers based on hyaluronic acid derivatives, rather than specifically serving as scaffolds, can be established by loading different osteoinductive or osteogenetic components and acquiring different release patterns to better enhance osteogenesis.
313
References
Osteoblasts in osteoporosis: past, emerging, and future anabolic targets
Pierre J. Marie,Moustapha Kassem +1 more
TL;DR: Current therapeutic approaches focused on intermittent parathyroid hormone and Wnt signaling agonists/antagonists targeting signaling pathways involved in osteoblastogenesis, based on selected full-text articles searched on Medline search from 1990 to 2010 are reviewed.
TNF-alpha and IL-1beta inhibit RUNX2 and collagen expression but increase alkaline phosphatase activity and mineralization in human mesenchymal stem cells.
J. Ding,Olfa Ghali,P. Lencel,Odile Broux,Christophe Chauveau,Jean-Christophe Devedjian,Pierre Hardouin,David Magne +7 more
TL;DR: The different effects of cytokines on TNAP activity and collagen expression may help explain why inflammation decreases bone formation in RA whereas it induces ectopic ossification from collagen-rich entheses during SpAs.
225
Osteocyte-Driven Bone Remodeling
Teresita Bellido,Teresita Bellido +1 more
- 01 Jan 2014
TL;DR: Osteocytes, the most abundant cells in bone, have been long postulated to detect and respond to mechanical and hormonal stimuli and to coordinate the function of osteoblasts and osteoclasts as mentioned in this paper.
222
Stem cell homing in musculoskeletal injury
TL;DR: Based on accruing evidence that the natural healing mechanism involves the recruitment of MSC and their subsequent reparative actions at the site of injury, the feasibility of the emerging strategy of instant stem-cell therapy will be proposed.
218
Harnessing and modulating inflammation in strategies for bone regeneration.
TL;DR: The distinction between regenerative and damaging inflammatory processes in bone is distinguished, recent in vitro and in vivo studies demonstrating how inflammation can be modulated to stimulate bone regeneration are summarized, and key future directions in the field are identified.
214