Inflammation and the Blood Microvascular System
Jordan S. Pober,William C. Sessa +1 more
TL;DR: Recent advances in understanding the roles played by microvessels in inflammation are reviewed, namely pericytes, and smooth muscle cells.
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Abstract: Acute and chronic inflammation is associated with changes in microvascular form and function At rest, endothelial cells maintain a nonthrombogenic, nonreactive surface at the interface between blood and tissue However, on activation by proinflammatory mediators, the endothelium becomes a major participant in the generation of the inflammatory response These functions of endothelium are modified by the other cell populations of the microvessel wall, namely pericytes, and smooth muscle cells This article reviews recent advances in understanding the roles played by microvessels in inflammation
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References
Getting to the site of inflammation: the leukocyte adhesion cascade updated
TL;DR: This Review focuses on new aspects of one of the central paradigms of inflammation and immunity — the leukocyte adhesion cascade.
4.4K
A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more
TL;DR: Blood vessel walls harbor a reserve of progenitor cells that may be integral to the origin of the elusive MSCs and other related adult stem cells.
4K
Nitric oxide synthases: regulation and function.
TL;DR: Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of NO synthase (NOS), which can be expressed in many cell types in response to lipopolysaccharide, cytokines, or other agents.
Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.
TL;DR: The history of investigations into pericytes, the mural cells of blood microvessels, are reviewed, emerging concepts are indicated, and problems and promise are pointed out.
2.5K
Evolving functions of endothelial cells in inflammation
Jordan S. Pober,William C. Sessa +1 more
TL;DR: This Review describes the functions performed by endothelial cells at each stage of the inflammatory process, emphasizing the principal mediators and signalling pathways involved and the therapeutic implications.
1.8K