Journal Article10.1056/NEJMRA010082
Infective endocarditis in adults.
TL;DR: This review article provides a comprehensive assessment of this serious infectious disease, including diagnostic challenges, cardiovascular and neurologic complications, and approaches to therapy.
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Abstract: The clinical features of this complex infection have changed in the past several decades. It is now an infection of older people, and mitral-valve prolapse is the most common predisposing cardiovascular problem in developed countries. In contrast, rheumatic heart disease is an important predisposing problem in developing countries. This review article provides a comprehensive assessment of this serious infectious disease, including diagnostic challenges, cardiovascular and neurologic complications, and approaches to therapy.
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References
Bartonella (Rochalimaea) species as a cause of apparent "culture-negative" endocarditis.
David H. Spach,Andrew S. Kanter,Nicholas A. Daniels,David J. Nowowiejski,Ann M. Larson,Rodney A. Schmidt,Bala Swaminathan,Don J. Brenner +7 more
TL;DR: A 39-year-old, homeless man who developed aortic valve endocarditis caused by B. quintana had a history of alcoholism and was seronegative for the human immunodeficiency virus.
Antibiotic treatment of adults with infective endocarditis due to streptococci, enterococci, staphylococci, and HACEK microorganisms. American Heart Association.
Walter R. Wilson,Adolf W. Karchmer,A. S. Dajani,Kathryn Taubert,Arnold S. Bayer,Donald Kaye,Alan L. Bisno,Patricia Ferrieri,Stanford T. Shulman,David T. Durack +9 more
TL;DR: Sufficient evidence has been published that recommendations regarding treatment of the most common microbiological causes of endocarditis are justified and there are insufficient published data to make a strong statement regarding the efficacy of specific therapeutic regimens for cases ofendocarditis due to microorganisms that uncommonly cause endocardritis.
Persistent fever in association with infective endocarditis.
TL;DR: Recording of patients at three hospital affiliates of Albert Einstein College of Medicine found persistent fever often indicates complicated endocarditis, and presents an approach for the evaluation of the patients affected by this condition.
Natural history of vegetations during successful medical treatment of endocarditis
TL;DR: Serial echocardiograms of patients with successful medical treatment for native valve infective endocarditis were reviewed to assess the presence and morphologic features of valvular vegetations at the onset and at the end of therapy, finding persistent vegetations are not independently associated with late complications.
Aortic Insufficiency in Bacterial Endocarditis
TL;DR: The records of 28 patients with bacterial endocarditis and aortic valve insufficiency were studied to determine clinical indications for valve replacement before bacteriologic cure can be cured.
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