Journal Article10.1007/S00044-014-0940-1
Indolizine: a biologically active moiety
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TL;DR: The present review discusses the versatile nature of indolizine derivatives and their possible mechanism of action, and provides information about current/future prospects of the topic and different indolIZine derivatives in clinical trials.
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Abstract: The discovery of camptothecin and its analogs was the major breakthrough through which “Indolizine moiety” came into limelight. Although major part of the research on indolizine derivatives is focused on anticancer drug discovery, these derivatives have also been screened for different biological activities such as antitubercular, antioxidant, antimicrobial, anticancer, and anti-inflammatory activities to name a few. Despite being an important medicinal moiety, a detailed review on the biologically active potential of indolizine derivative is unavailable. To the best of our knowledge, previous reviews on indolizine derivatives mainly focused on their chemistry and synthesis. The present review discusses the versatile nature of indolizine derivatives and their possible mechanism of action. Important SAR points are discussed with each study to highlight the rationale behind the study. Furthermore, the present review also provides information about current/future prospects of the topic and different indolizine derivatives in clinical trials.
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Citations
Pharmacophore mapping studies on indolizine derivatives as 15-LOX inhibitors
TL;DR: The present model is based on a dataset of 47 indolizine derivatives that exhibit inhibition against 15-LOX enzyme isolated from soybeans and suggested that pharmacophore modeling approach could be used as a tool for the development of lead structures.
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Visible Light Promoted, Photocatalyst Free C(sp2)–H Bond Functionalization of Indolizines via EDA Complexes
TL;DR: In this paper , the photo-driven cross dehydrogenative coupling (CDC) reaction initiated by electron donor-acceptor (EDA) complexes between electron rich indolizines and electron poor quinones has been demonstrated.
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Pyrrole-Based Enaminones as Building Blocks for the Synthesis of Indolizines and Pyrrolo[1,2-a]pyrazines Showing Potent Antifungal Activity
Diter Miranda-Sánchez,Carlos H. Escalante,Dulce Andrade-Pavón,Omar Gómez-García,Edson Barrera,Lourdes Villa-Tanaca,Francisco Delgado,Joaquín Tamariz +7 more
TL;DR: Docking analysis suggests that the inhibition of yeast growth was probably mediated by the interaction of the compounds with the catalytic site of HMGR of the Candida species.
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Regioselective Annulation of N-Methylpyridinium Ylides with Alkenes Enabled by Palladium Catalysis: Access to 3-Unsubstituted Indolizine Derivatives
Quan Gou,Qianhua Zhu,Mengjiao Deng,Weiwei Li,Xing-Rui Ran,Jian R. Xie,Huisheng Huang,Xiaoping Tan,Min‐Jie Zhu +8 more
TL;DR: The first catalytic protocol for regioselective [3+2] annulation of N-methyl pyridinium ylides with alkenes to establish various valuable 3-unsubstituted indolizine derivatives is accomplished by palladium catalysis in the unactivated position.
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Synthesis of 3‑alkyl and 1,3-Bis(alkyl)indolizine amides from α-bromohydroxamates
TL;DR: In this article , a simple and catalyst-free method was developed for the synthesis of hindered indolizine amide derivatives from functionalized alkyl bromides using azaoxyallyl cations generated in situ from α-bromoamides.
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