Indole synthesis: a review and proposed classification
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TL;DR: A framework for the classification of all indole syntheses is presented, and it is apparent that every indole synthesis must fit one or the other of the nine strategic approaches adumbrated here.
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About: This article is published in Tetrahedron. The article was published on 23 Sep 2011. and is currently open access. The article focuses on the topics: Indole test.
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Citations
Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones
TL;DR: This review aims to cover the literature on asymmetric quaternary carbons, 2-substituted and 2,2'-disubtituted 3-indolinones, from its origin to the end of 2011.
635
Indole synthesis – something old, something new
TL;DR: In this article, a general approach would start from a mono-functionalized arene such as an aniline or halobenzene, followed by cyclization with C-C or C-N bond formation to an unactivated C-H bond.
604
Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view.
Navriti Chadha,Om Silakari +1 more
TL;DR: An overview of the chemistry, biology, and toxicology of indoles focusing on their application as drugs is provided to corroborate the information available on the natural indole alkaloids, indole based FDA approved drugs and clinical trial candidates having diverse therapeutic implementations.
516
Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives.
Archana Kumari,Rajesh K. Singh +1 more
TL;DR: This review summarizes some of the recent effective chemical synthesis (2014-2018) for indole ring and emphasized on the structure-activity relationship (SAR) to reveal the active pharmacophores of various indole analogues accountable for anticancer, anticonvulsant, antimicrobial, antitubercular, antimalarial, antiviral, antidiabetic and other miscellaneous activities which have been investigated in the last five years.
427
Beyond C2 and C3: Transition-Metal-Catalyzed C–H Functionalization of Indole
TL;DR: This review focuses on the contributions made in benzenoid C–H functionalization of indoles and other related heteroaromatics such as carbazoles.
References
Oxidative cyclization of amino alcohols catalyzed by a CpIr complex. Synthesis of indoles, 1,2,3,4-tetrahydroquinolines, and 2,3,4,5-tetrahydro-1-benzazepine.
TL;DR: A new iridium-catalyzed oxidative cyclization of amino alcohols has been revealed andIndole derivatives are synthesized in good to excellent yields from 2-aminophenethyl alcohols by means of a [CpIrCl(2)](2)/K(2)CO(3) catalytic system.
Palladium-catalyzed oxidative cyclization of N-aryl enamines: from anilines to indoles.
TL;DR: An efficient synthesis of functionalized indoles from commercially available anilines by palladiumcatalyzed, intramolecular oxidative coupling is reported, with the ability to vary the aniline moiety so broadly is a distinct advantage of this new indole synthesis.
Novel chemistry of indole in the synthesis of heterocycles
TL;DR: In this paper, the first generation and successful electrophilic trapping of a 2,3-dilithioindole from indoles has been achieved, and a ring system furo(3,4-b)pyrrole is described for the first time.
A Palladium-Catalyzed Method for the Preparation of Indoles via the Fischer Indole Synthesis
TL;DR: A Pd-catalyzed method for the preparation of N-aryl benzophenone hydrazones 4, followed by a hydrolysis/Fischer cyclization protocol, affords N- Darylindole products in good yields and provides a means for the prepared of a structurally diverse set of indoles from simple, (usually) commercially available precursors.