Indole synthesis: a review and proposed classification
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TL;DR: A framework for the classification of all indole syntheses is presented, and it is apparent that every indole synthesis must fit one or the other of the nine strategic approaches adumbrated here.
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About: This article is published in Tetrahedron. The article was published on 23 Sep 2011. and is currently open access. The article focuses on the topics: Indole test.
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Citations
Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones
TL;DR: This review aims to cover the literature on asymmetric quaternary carbons, 2-substituted and 2,2'-disubtituted 3-indolinones, from its origin to the end of 2011.
635
Indole synthesis – something old, something new
TL;DR: In this article, a general approach would start from a mono-functionalized arene such as an aniline or halobenzene, followed by cyclization with C-C or C-N bond formation to an unactivated C-H bond.
604
Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view.
Navriti Chadha,Om Silakari +1 more
TL;DR: An overview of the chemistry, biology, and toxicology of indoles focusing on their application as drugs is provided to corroborate the information available on the natural indole alkaloids, indole based FDA approved drugs and clinical trial candidates having diverse therapeutic implementations.
516
Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives.
Archana Kumari,Rajesh K. Singh +1 more
TL;DR: This review summarizes some of the recent effective chemical synthesis (2014-2018) for indole ring and emphasized on the structure-activity relationship (SAR) to reveal the active pharmacophores of various indole analogues accountable for anticancer, anticonvulsant, antimicrobial, antitubercular, antimalarial, antiviral, antidiabetic and other miscellaneous activities which have been investigated in the last five years.
427
Beyond C2 and C3: Transition-Metal-Catalyzed C–H Functionalization of Indole
TL;DR: This review focuses on the contributions made in benzenoid C–H functionalization of indoles and other related heteroaromatics such as carbazoles.
References
Regioselective Fischer indole synthesis mediated by organoaluminum amides
TL;DR: In particular, diethylaluminum 2,2,6,6-tetramethylpiperidide (DATMP) is the reagent of choice for regioselective Fischer indole synthesis as mentioned in this paper.
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An expedient synthesis of substituted indoles
Amos B. Smith,Melean Visnick +1 more
TL;DR: Condensation of carboxylic acid esters with organodilithium reagents derived from N-trimethylsilyl-o-toluidine or N-Trimethyl silyl -o-ethyl aniline affords substituted indoles.
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