Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells
Esen Sefik,Naama Geva-Zatorsky,Sungwhan F. Oh,Liza Konnikova,David Zemmour,Abigail Manson McGuire,Dalia Burzyn,Adriana Ortiz-Lopez,Mercedes Lobera,Jianfei Yang,Shomir Ghosh,Ashlee M. Earl,Scott B. Snapper,Ray Jupp,Dennis L. Kasper,Diane Mathis,Diane Mathis,Christophe Benoist,Christophe Benoist +18 more
TL;DR: It is reported that symbiotic members of the human gut microbiota induce a distinct Treg population in the mouse colon, which constrains immuno-inflammatory responses.
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Abstract: T regulatory cells that express the transcription factor Foxp3 (Foxp3+ Tregs) promote tissue homeostasis in several settings. We now report that symbiotic members of the human gut microbiota induce a distinct Treg population in the mouse colon, which constrains immuno-inflammatory responses. This induction—which we find to map to a broad, but specific, array of individual bacterial species—requires the transcription factor Rorγ, paradoxically, in that Rorγ is thought to antagonize FoxP3 and to promote T helper 17 (TH17) cell differentiation. Rorγ’s transcriptional footprint differs in colonic Tregs and TH17 cells and controls important effector molecules. Rorγ, and the Tregs that express it, contribute substantially to regulating colonic TH1/TH17 inflammation. Thus, the marked context-specificity of Rorγ results in very different outcomes even in closely related cell types.
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Citations
Spatiotemporal and cell-state control of antigen presentation during tolerance and immunity.
Jyh Liang Hor,Ronald N. Germain +1 more
TL;DR: In this paper , the authors focus on two opposing aspects of adaptive immunity: tolerance and antitumor immunity, to illustrate how a complex set of antigen presentation mechanisms contributes to maintaining a delicate balance between robust immunity and avoidance of autoimmune pathology.
Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt+ T cells.
Mari Tenno,Alicia Yoke Wei Wong,Mika Ikegaya,Eiji Miyauchi,Wooseok Seo,Peter See,Tamotsu Kato,Takashi Taida,Michiko Ohno-Oishi,Hiroshi Ohno,Hideyuki Yoshida,Florent Ginhoux,Florent Ginhoux,Ichiro Taniuchi +13 more
- 01 Jan 2020
TL;DR: It is revealed that Runx/Cbfβ complexes play crucial and complementary roles in cDCs and Th cells to shape converging type 3 immune responses and a Runx-binding enhancer in the Rorc gene is essential for T cells to integrate cDC-derived signals to induce Rorγt expression.
Infant gut microbiome reprogramming following introduction of solid foods (weaning)
Mengfan Ding,R. Paul Ross,Eugene Dempsey,Bowen Li,Catherine Stanton +4 more
TL;DR: This review examines the infant gut microbiome's transformation during weaning, a period of major shifts in microbiome composition and function, influenced by diet and perinatal factors, with lasting effects into adulthood.
Selective ablation of thymic and peripheral Foxp3+ regulatory T cell development
Açelya Yilmazer,D. M. Zevla,Rikke Malmkvist,Carlos Alejandro Bello Rodríguez,Pablo Undurraga,Emre Kirgin,Marie Boernert,David Voehringer,Olivia Kershaw,Susan M. Schlenner,Karsten Kretschmer +10 more
TL;DR: PTreg cells exhibit an unexpectedly high functional adaptability, emphasizing their importance as mediators of bystander effects to ensure self-tolerance, and are identified as primary regulators of β-cell autoimmunity in type 1 diabetes.
Eosinophils Contribute to Oral Tolerance via Induction of RORγt-Positive Antigen-Presenting Cells and RORγt-Positive Regulatory T Cells
Shunjiro Kurihara,Kotaro Suzuki,Masaya Yokota,Takashi Ito,Yuki Hayashi,Ryo Kikuchi,Takahiro Kageyama,Kazuyuki Meguro,Shigeru Tanaka,Arifumi Iwata,Yoshiyuki Goto,Akira Suto,Hiroshi Nakajima +12 more
TL;DR: The results suggest that eosinophils are crucial in the induction of oral tolerance, possibly via the induction of RORγt+ APCs and RORγt+ Tregs.
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