Increasing venoarterial extracorporeal membrane oxygenation flow negatively affects left ventricular performance in a porcine model of cardiogenic shock

TL;DR: High flow VA-ECMO support significantly reduced LV end-diastolic pressure, end-diastolic volume, stroke work, and PVA compared to minimal support, and mean arterial pressure was stable at the highest and lowest flows.

TL;DR: Preclinical models of cardiogenic shock improve outcome by replicating the physiopathology and hemodynamic phenotype of the condition, allowing for investigation of therapeutic strategies and mitigation of systemic inflammatory reaction.

TL;DR: This multicenter study (EVACS) compares ECMO alone versus ECPELLA in cardiogenic shock patients, finding similar 30-day and 1-year mortality rates, with no significant differences in complications, suggesting both strategies are effective for mechanical circulatory support.

TL;DR: Peripheral VA-ECMO restored systemic perfusion but induced a significant and blood flow-dependent increase in left ventricular preload and afterload and significantly decreased p38-MAPK phosphorylation and cardiac myocyte apoptosis in the border zone.

TL;DR: Despite the need for effective mechanical circulatory support in CSMI, current devices, as tested, have not been demonstrated to improve short- or long-term survival rates.

TL;DR: Large animal models recapitulating the clinical HF phenotype in large animal models can allow for the translation of basic science discoveries into clinical therapies and translate basic science to clinical applications have successfully traveled the journey from bench to bedside.

TL;DR: In this paper, the authors used large animal models of congestive heart failure (HF) for the elucidation of biological pathways involved in HF and the development and refinement of HF therapies.