Increased Intestinal Permeability Is Associated with the Development of Multiple Organ Dysfunction Syndrome in Critically Ill ICU Patients

TL;DR: The ‘gut origin’ theory proposes that a variety of local and/or systemic insults result in depression of the intestine’s physiological function, specifically the loss of its protective barrier function, which could trigger, exaggerate, and perpetuate the systemic inflammatory response that occurs in MODS.

TL;DR: MODS has an extraordinarily high mortality and, for many patients, the support of this syndrome does not improve survival but rather prolongs the dying process.

TL;DR: The form and validation results of APACHE II, a severity of disease classification system, are presented, showing an increasing score was closely correlated with the subsequent risk of hospital death for 5815 intensive care admissions from 13 hospitals.

TL;DR: An American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference was held in Northbrook in August 1991 with the goal of agreeing on a set of definitions that could be applied to patients with sepsis and its sequelae as mentioned in this paper.

TL;DR: This multiple organ dysfunction score, constructed using simple physiologic measures of dysfunction in six organ systems, mirrors organ dysfunction as the intensivist sees it and correlates strongly with the ultimate risk of ICU mortality and hospital mortality.

TL;DR: If other intensivists incorporate this system into their experience, meaningful comparisons between intensive care units can occur and the cost of intensive care relative to the extent of care offered can occur.