Journal Article10.1016/J.BIOPSYCH.2006.05.048
Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features.
TL;DR: Depressed individuals also display decreased relationships between amygdala and DLPFC activity, potentially signifying decreased functional relationships among these structures, though these may reflect separate mechanisms.
read more
About: This article is published in Biological Psychiatry. The article was published on 15 Jan 2007. The article focuses on the topics: Dorsolateral prefrontal cortex & Prefrontal cortex.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Rapid neuroplasticity changes and response to intravenous ketamine: a randomized controlled trial in treatment-resistant depression
Jared M. Kopelman,Timothy A. Keller,Benjamin Panny,Angela Griffo,Michelle Degutis,Crystal Spotts,Nicolas Cruz,Elizabeth C Bell,Kevin Do-Nguyen,Meredith L. Wallace,Sanjay J. Mathew,Robert H Howland,Rebecca B. Price +12 more
TL;DR: This article quantified gray matter microstructural changes on a rapid (24-h) timescale within key regions where neuroplasticity enhancements post-ketamine have been implicated in animal models.
Cortico-amygdalar maturational coupling is associated with depressive symptom trajectories during adolescence.
Nandita Vijayakumar,Nicholas B. Allen,Meg Dennison,Michelle L. Byrne,Julian G Simmons,Sarah Whittle +5 more
TL;DR: Findings highlight significant associations between cortico‐amygdalar maturational coupling and the emergence of depressive symptoms during adolescence, suggesting that synchronous development of these regions might support more adaptive affect regulation and functioning.
24
Toward an Understanding of the Neural Circuitry of Major Depressive Disorder Through the Clinical Response to Deep Brain Stimulation of Different Anatomical Targets
TL;DR: Deep brain stimulation has been proposed as a treatment for treatment-resistant depression and the target regions with the most evidence to support their use are the subcallosal cingulate, ventral capsule/ventral striatum, nucleus accumbens, and medial forebrain bundle.
Long-Term Neuroanatomical Consequences of Childhood Maltreatment: Reduced Amygdala Inhibition by Medial Prefrontal Cortex.
Roman Kessler,Roman Kessler,Simon Schmitt,Simon Schmitt,Torsten Sauder,Frederike Stein,Frederike Stein,Dilara Yüksel,Dilara Yüksel,Dominik Grotegerd,Udo Dannlowski,Tim Hahn,Astrid Dempfle,Jens Sommer,Jens Sommer,Olaf Steinsträter,Olaf Steinsträter,Igor Nenadic,Igor Nenadic,Tilo Kircher,Tilo Kircher,Andreas Jansen,Andreas Jansen +22 more
TL;DR: A mechanistic explanation for the amygdala hyperactivity in subjects with particular risk for depression, in particular childhood maltreatment, is proposed, caused by a malfunctioned amygdala downregulation via the medial prefrontal cortex.
Brain Activity and Network Interactions in the Impact of Internal Emotional Distraction.
TL;DR: Functional MRI data showed reduced response in brain regions associated with the salience network, coupled with greater recruitment of executive prefrontal and memory-related temporoparietal regions, and with increased frontopariet connectivity, when subjects focused on nonemotional contextual details of their memories.
24
References
AFNI: software for analysis and visualization of functional magnetic resonance neuroimages
TL;DR: A package of computer programs for analysis and visualization of three-dimensional human brain functional magnetic resonance imaging (FMRI) results is described and techniques for automatically generating transformed functional data sets from manually labeled anatomical data sets are described.
11.3K
The Emotional Brain
Joseph E. LeDoux
- 01 Jan 1996
TL;DR: In The Emotional Brain, Joseph LeDoux investigates the origins of human emotions and explains that many exist as part of complex neural systems that evolved to enable us to survive.
A Hot/Cool-System Analysis of Delay of Gratification: Dynamics of Willpower.
Janet Metcalfe,Walter Mischel +1 more
TL;DR: A 2-system framework is proposed for understanding the processes that enable--and undermine--self-control or "willpower" as exemplified in the delay of gratification paradigm, and a cool, cognitive "know" system and a hot, emotional "go" system are postulated.
Rethinking Feelings: An fMRI Study of the Cognitive Regulation of Emotion
TL;DR: Functional magnetic resonance imaging findings support the hypothesis that prefrontal cortex is involved in constructing reappraisal strategies that can modulate activity in multiple emotion-processing systems.
Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness
Helen S. Mayberg,Mario Liotti,Stephen K. Brannan,Scott M. McGinnis,Roderick K. Mahurin,Paul A Jerabek,J. Arturo Silva,Janet L. Tekell,C. C. Martin,Jack L. Lancaster,Peter T. Fox +10 more
TL;DR: Reciprocal changes involving subgenual cingulate and right prefrontal cortex occur with both transient and chronic changes in negative mood, suggesting that these regional interactions are obligatory and probably mediate the well-recognized relationships between mood and attention seen in both normal and pathological conditions.
2.4K