Journal Article10.1016/J.BIOPSYCH.2006.05.048
Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features.
TL;DR: Depressed individuals also display decreased relationships between amygdala and DLPFC activity, potentially signifying decreased functional relationships among these structures, though these may reflect separate mechanisms.
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About: This article is published in Biological Psychiatry. The article was published on 15 Jan 2007. The article focuses on the topics: Dorsolateral prefrontal cortex & Prefrontal cortex.
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Citations
Structural and Functional Abnormities of Amygdala and Prefrontal Cortex in Major Depressive Disorder With Suicide Attempts.
Lifei Wang,Yimeng Zhao,Elliot Kale Edmiston,Fay Y. Womer,Ran Zhang,Pengfei Zhao,Xiaowei Jiang,Feng Wu,Lingtao Kong,Yifang Zhou,Yanqing Tang,Shengnan Wei +11 more
TL;DR: Findings provide evidence that the amygdala and PFC may be closely related to the pathogenesis of suicidal behavior in MDD and implicate the amygdala-ventral/medial PFC circuit as a potential target for suicide intervention.
Newborn amygdala connectivity and early emerging fear.
Elina Thomas,Claudia Buss,Jerod M. Rasmussen,Sonja Entringer,Julian S.B. Ramirez,Mollie Marr,Marc D. Rudolph,John H. Gilmore,Martin Styner,Pathik D. Wadhwa,Damien A. Fair,Alice M. Graham +11 more
TL;DR: Investigation of newborn Am-Ins and Am-vmPFC resting state functional connectivity in relation to developmental trajectories of fear and sadness over the first two years of life finds specificity is observed, such that connections relevant for fear development are distinct from those predicting sadness trajectories.
54
Affective and neuroendocrine stress reactivity to an academic examination: influence of the 5-HTTLPR genotype and trait neuroticism
Ellen Verschoor,C. Rob Markus +1 more
TL;DR: Vulnerability to real-life stressors is an important risk factor for depression pathogenesis, this may be a mediating factor making S/S-allele carriers more susceptible for depression symptoms.
54
Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression
Sarah Ann R. Anderson,Michael Michaelides,Parisa Zarnegar,Yanhua Ren,Pernilla Fagergren,Panayotis K. Thanos,Gene-Jack Wang,Michael J. Bannon,John F. Neumaier,Eva Keller,Nora D. Volkow,Yasmin L. Hurd +11 more
TL;DR: A translational study supports a functional role for impaired Pdyn in the PAC in opiate abuse through activation of the stress and negative affect neurocircuitry implicated in addiction vulnerability.
Vascular growth factors in neuropsychiatry
TL;DR: Obtaining insight into the behavioral, cellular and molecular actions of multi-functional trophic factors has the potential to open new and transformative therapeutic approaches.
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