Incomplete and late recovery of sudden olfactory dysfunction in COVID-19.
Eduardo Macoto Kosugi,Joel Lavinsky,Fabrizio Ricci Romano,Marco Aurélio Fornazieri,Gabriela Ricci Luz-Matsumoto,Marcus Miranda Lessa,Otavio Bejzman Piltcher,Geraldo Druck Sant’Anna +7 more
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TL;DR: Positive-COVID-19 patients with sudden olfactory dysfunction showed lower total recovery rate and longer duration than negative-COIDs patients, and individuals with sudden hyposmia completely recovered more often than the ones with sudden anosmia.
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Abstract: Introduction Sudden olfactory dysfunction is a new symptom related to COVID-19, with little data on its duration or recovery rate. Objective To characterize patients with sudden olfactory dysfunction during the COVID-19 pandemic, especially their recovery data. Methods An online survey was conducted by the Brazilian Society of Otorhinolaryngology and Cervico-Facial Surgery, and Brazilian Academy of Rhinology, including doctors who assessed sudden olfactory dysfunction patients starting after February 1st, 2020. Participants were posteriorly asked by e-mail to verify data on the recovery of sudden olfactory loss and test for COVID-19 at the end of the data collection period. Results 253 sudden olfactory dysfunction patients were included, of which 59.1% were females with median age of 36 years, with a median follow-up period of 31 days. 183 patients (72.3%) had been tested for COVID-19, and of those 145 (79.2%) tested positive. Patients that tested positive for COVID-19 more frequently showed non-specific inflammatory symptoms (89.7% vs. 73.7%; p = 0.02), a lower rate of total recovery of sudden olfactory dysfunction (52.6% vs. 70.3%; p = 0.05) and a longer duration to achieve total recovery (15 days vs. 10 days; p = 0.0006) than the ones who tested negative for COVID-19. Considering only positive-COVID-19 patients, individuals with sudden hyposmia completely recovered more often than the ones with sudden anosmia (68.4% vs. 50.0%; p = 0.04). Conclusion Positive-COVID-19 patients with sudden olfactory dysfunction showed lower total recovery rate and longer duration than negative-COVID-19 patients. Additionally, total recovery was seen more frequently in positive-COVID-19 patients with sudden hyposmia than the ones with sudden anosmia.
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Neuromuscular presentations in patients with COVID-19.
TL;DR: All published reports on SARS-CoV-2-related peripheral nerve, neuromuscular junction, muscle, and cranial nerve disorders are analyzed and olfactory and gustatory dysfunction is now accepted as an early manifestation of COVID-19 infection.
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Anosmia and dysgeusia in SARS-CoV-2 infection: Incidence and effects on COVID-19 severity and mortality, and the possible pathobiology mechanisms - a systematic review and meta-analysis
Endang Mutiawati,Marhami Fahriani,Sukamto S. Mamada,Jonny Karunia Fajar,Jonny Karunia Fajar,Andri Frediansyah,Helnida Anggun Maliga,Muhammad Ilmawan,Talha Bin Emran,Youdiil Ophinni,Ichsan Ichsan,Nasrul Musadir,Ali A. Rabaan,Kuldeep Dhama,Syahrul Syahrul,Firzan Nainu,Harapan Harapan +16 more
TL;DR: In this article, the authors determined the global prevalence of anosmia and dysgeusia in coronavirus disease 2019 (COVID-19) patients and assessed their association with severity and mortality.
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Onset and duration of symptoms of loss of smell/taste in patients with COVID-19: A systematic review.
Renata Emmanuele Assunção Santos,Maria Giselda da Silva,Maria Caroline Barbosa do Monte Silva,Danielly Alves Mendes Barbosa,Ana Lisa do Vale Gomes,Lígia Cristina Monteiro Galindo,Raquel da Silva Aragão,Kelli Nogueira Ferraz-Pereira +7 more
TL;DR: In this article, the authors conducted a systematic review of the literature to investigate the time of onset and duration of symptoms of loss of smell and taste in patients diagnosed with COVID-19.
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Olfactory Dysfunction in COVID-19 Patients: Prevalence and Prognosis for Recovering Sense of Smell.
Luca D'Ascanio,Manlio Pandolfini,Cristina Cingolani,Gino Latini,Paolo Gradoni,Maria Capalbo,Gabriele Frausini,Massimo Maranzano,Michael Brenner,Arianna Di Stadio +9 more
TL;DR: Prevalence and severity of subjective loss of smell in outpatients and inpatients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection vs healthy controls are analyzed, suggesting favorable prognosis for olfaction.
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TL;DR: Older Americans with measured olfactory dysfunction are unlikely to report it, and those who lack awareness of this dysfunction have distinct demographic, social, and cognitive characteristics.
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