Journal Article10.1016/J.BIOMATERIALS.2007.11.005
In vivo bone formation from human embryonic stem cell-derived osteogenic cells in poly(d,l-lactic-co-glycolic acid)/hydroxyapatite composite scaffolds.
Sinae Kim,Sang-Soo Kim,Sang-Soo Kim,Soo-Hong Lee,Seong Eun Ahn,So-Jung Gwak,Joon Ho Song,Byung Soo Kim,Hyung-Min Chung +8 more
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TL;DR: OC-hESCs successfully regenerated bone tissue upon in vivo implantation, and this regeneration can be further enhanced by the administration of BMP-2, which enhanced new bone tissue formation in terms of mineralization and the expression of bone-specific genetic markers.
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About: This article is published in Biomaterials. The article was published on 01 Mar 2008. The article focuses on the topics: Bone regeneration & Bone tissue.
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Biomimetic polymer scaffolds to promote stem cell-mediated osteogenesis.
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References
Embryonic Stem Cell Lines Derived from Human Blastocysts
James A. Thomson,Joseph Itskovitz-Eldor,Sander S. Shapiro,Michelle A. Waknitz,Swiergiel Jennifer J,Vivienne S. Marshall,Jeffrey M. Jones +6 more
TL;DR: Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages.
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Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
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Osteogenic differentiation of purified, culture‐expanded human mesenchymal stem cells in vitro
TL;DR: In this paper, a reproducible system for the in vitro osteogenic differentiation of human mesenchymal stem cells (MSCs) was presented. But the authors did not consider the effect of changes in the microenvironment upon the process.
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Tissue Engineering--Current Challenges and Expanding Opportunities
Linda G. Griffith,Gail Naughton +1 more
TL;DR: In the future, engineered tissues could reduce the need for organ replacement, and could greatly accelerate the development of new drugs that may cure patients, eliminating theneed for organ transplants altogether.
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Bone Tissue Engineering: State of the Art and Future Trends
TL;DR: The present review pretends to give an exhaustive overview on all components needed for making bone tissue engineering a successful therapy, going from materials to scaffolds and from cells to tissue engineering strategies that will lead to "engineered" bone.