1. What are the contributions in "N-vitro release study of hydrophobic drug using electrospun ross-linked gelatin nanofibers" ?
Here the authors report the synthesis of gelatin nanofibers by electrospinning, followed by testing them as a potential carrier for oral drug delivery system for a model hydrophobic drug, piperine.
read more
![Fig. 1 summarizes the effect of crosslinking on GNF. Fig. 1a epresents the non-crosslinked GNF membrane with aluminum oil. Lysine is one of the amino acids present in gelatin, which s responsible for crosslinking with aldehyde group of GTA [31]. fter crosslinking, sample shrinks as shown in Fig. 1b. Therefore, embranes are not peeled from aluminum foil in order to avoid xcessive shrinkage of membrane on cross linking. Fig. 1c shows he stability of crosslinked gelatin nanofiber membrane in aqueus medium even after keeping immersed. In-vitro biodegradation tudy was then done with the aim to check the stability of samples p to 24 h. GNF and G-P NF membrane with different crosslinking ime are summarized in Table 1. Samples with different crosslinkng time (non-cross-linked i.e., 0 min and cross-linked for 2, 4, 6, 8 nd 10 min) were undergone the degradation at different pH (1.2,](/figures/fig-1-summarizes-the-effect-of-crosslinking-on-gnf-fig-1a-k6n666r3.webp)