In vitro antibacterial activity of andrographolide and hordenine against methicillin-resistant Staphylococcus aureus and Staphylococcus aureus
S. J. Vidyavarsha,Bibu John Kariyil,Varsha Unni,Jess Vergis,Sanis Juliet,Preethy John,R. Anoopraj +6 more
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TL;DR: The results of the study revealed that both andrographolide and hordenine at various concentrations did not show any zone of inhibition against MRSA and S. aureus.
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Abstract: Bacterial infections are difficult to treat, especially those infected with resistant bacteria. Due to the haphazard use of antibiotics in humans and animals, methicillin-resistant Staphylococcus aureus (MRSA) has developed resistance to practically all commercially available antibacterial drugs. Exploring natural plant compounds with antibacterial activity could be beneficial in the treatment of infections with MRSA and Staphylococcus aureus. Andrographolide, a labdane diterpenoid derived from Andrographis paniculata, and Hordenine, a phenethylamine alkaloid found in Hordeum vulgare, are reported to have antibacterial activity. In the present study, the antibacterial activity of andrographolide and hordenine was tested against MRSA and S. aureus using the Kirby- Bauer agar disc diffusion method and the modified resazurin microtiter plate assay. The results of the study revealed that both andrographolide and hordenine at various concentrations did not show any zone of inhibition against MRSA and S. aureus. Hordenine showed an MIC of 1000 μg/mL against MRSA and S. aureus, but andrographolide had no effect on both MRSA and S. aureus.
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Citations
Antibacterial Activity and Antifungal Activity of Monomeric Alkaloids
Amin Mahmood Thawabteh,Aseel Wasel Ghanem,Sara AbuMadi,Dania Thaher,Weam Jaghama,Rafik Karaman,Laura Scrano,Sabino Aurelio Bufo +7 more
TL;DR: This study examines 248 monomeric alkaloids for antibacterial and antifungal activity, identifying 16 compounds with strong activity against Gram-positive and Gram-negative microorganisms, highlighting their potential for novel antimicrobial drug development.
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•Journal Article
Undetectable anti-bacterial activity of Andrographis paniculata (Burma) wall. ex ness.
TL;DR: It is found that anti-bacterial activity of AP is undetectable in this study and was not demonstrable even in a solution containing 25,000 mg per litres of crude powder.
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Enzymatic synthesis and antibacterial activity of andrographolide derivatives
TL;DR: Results indicate an enzymatic modification was not only facile and green, but an effective method for the preparation of an andrographolide monoester, showing antibacterial activity against representative Gram-positive and Gram-negative bacteria.
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Antimicrobial activity of liquid residues of Cymbopogon citratus oil extracts
Taghreed K. Mohammed,Nahla Aqel,Emad A. S. Al-Dujaili +2 more
- 01 Nov 2020
TL;DR: The liquid residues of ethanolic and aqueous extracts of Lemongrass showed antimicrobial effect against all the test microorganisms including Pseudomonas aeruginosa, which can be suggested that these extracts may be used for skin treatment in burned patients infected with pathogenic microorganisms.
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Multi-drug-resistant Staphylococcus aureus and future chemotherapy
Keiichi Hiramatsu,Yuki Katayama,Miki Matsuo,Takashi Sasaki,Yuh Morimoto,A. Sekiguchi,Tadashi Baba +6 more
TL;DR: The genetic basis for the remarkable ability of S. aureus to acquire multi-antibiotic resistance is described, and a novel paradigm for future chemotherapy against the multi-resistant pathogens is proposed.