Journal Article10.1007/BF00303136
In vitro absorption of some chlorinated paraffins through human skin
9
TL;DR: These chlorinated paraffins were very poorly absorbed through human skin and human dermal exposure should not cause significant systemic levels.
read more
Abstract: The in vitro absorption of chlorinated paraffins, Cereclor S52 and Cereclor 56L (present in a cutting fluid), has been measured through human skin. During 56 h continuous skin contact no Cereclor S52 was detected to have been absorbed and only a very slow rate of Cereclor 56L absorption (mean rate, 0.04 micrograms/cm/h) was measured. This rate was only apparent after more than 7 h continuous skin contact. These chlorinated paraffins were very poorly absorbed through human skin and human dermal exposure should not cause significant systemic levels.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
To what extent are biomonitoring data available in chemical risk assessment
TL;DR: This investigation was focused on workplace exposures and on urinary biomarkers of exposure, and it was concluded that in some cases, biomonitoring data are either lacking or scarce.
7
Evidence for cosmetics as a source of mineral oil contamination in women.
Nicole Concin,Gerda Hofstetter,Barbara Plattner,Caroline Tomovski,Katell Fiselier,Kerstin Gerritzen,Severin Semsroth,Alain G. Zeimet,Christian Marth,Harald Siegl,Karl Rieger,Hanno Ulmer,Hans Concin,Koni Grob +13 more
TL;DR: The increase in MOSH concentration in human fat tissue with age suggests an accumulation over time, and cosmetics might be a relevant source of the contamination.
A toxicological review of topical exposure to white mineral oils.
TL;DR: In contrast to these subchronic oral studies, repeated topical exposure to white mineral oils has not been found to produce liver granulomas, histiocytosis in the mesenteric or other lymph nodes, or any local or systemic toxicity including tumour formation in Fischer 344 rats, C3H mice, New Zealand White rabbits or beagle dogs at similar or higher exposures (mg/kg/day).
Chlorinated paraffins and tris (1-chloro-2-propyl) phosphate in spray polyurethane foams – A source for indoor exposure?
TL;DR: Investigation of chemical additives present in new and used spray polyurethane foams and the dermal transfer through direct contact shows that cured do-it-yourself spray one-component SPFs often contain chlorinated paraffins, and tris (1-chloro-2-propyl) phosphate (TCIPP), and could suggest an unnecessary use of high CPs/TCIPP concentrations in OCFs.
References
Comparison of the in vivo and in vitro percutaneous absorption of a lipophilic molecule (cypermethrin, a pyrethroid insecticide)
Robert C. Scott,John D. Ramsey +1 more
TL;DR: The percutaneous absorption in vitro technique using epidermal membranes was successfully used with this lipophilic chemical to predict the in vivo absorption in the rat, indicating that cypermethrin would be less readily absorbed in humans than in the rats.
58
The in vitro hydrolysis of diisopropyl fluorophosphate during penetration through human full-thickness skin and isolated epidermis.
TL;DR: In vitro investigation of the degree of hydrolysis of diisopropyl fluorophosphate in skin suspensions and during penetration through isolated epidermis and full-thickness skin from humans found that the concentration in the skin was proportional to the penetration rate, thus indicating that the enzymatic degree of Hydrolysis depends upon the Penetration rate.
24
Percutaneous and oral absorption of chlorinated paraffins in the rat.
TL;DR: It is shown that rat skin acts as an effective barrier to chlorinated paraffins containing eighteen or more carbons and more than 40% chlorine by weight and can be estimated to be nearly 100 times greater than its dermal absorp tion.
20
Mechanism of percutaneous absorption. IV. Penetration of nonelectrolytes (alcohols) from aqueous solutions and from pure liquids.
TL;DR: It is shown that with the aid of a few simple principles and a knowledge of the solubility character of the vehicle, the permeation of different substances can be qualitatively predicted.