Journal Article10.1042/CS0950115
In utero programming of chronic disease
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TL;DR: This review examines the evidence linking these diseases to fetal undernutrition and provides an overview of previous studies in this area.
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Abstract: 1 Many human fetuses have to adapt to a limited supply of nutrients In doing so they permanently change their structure and metabolism 2 These 'programmed' changes may be the origins of a number of diseases in later life, including coronary heart disease and the related disorders stroke, diabetes and hypertension 3 This review examines the evidence linking these diseases to fetal undernutrition and provides an overview of previous studies in this area
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C. N. Hales,David J.P. Barker,Penelope M.S. Clark,Lorna Cox,Caroline H.D. Fall,Clive Osmond,P D Winter +6 more
TL;DR: Reduced growth in early life is strongly linked with impaired glucose tolerance and non-insulin dependent diabetes and reduced early growth is also related to a raised plasma concentration of 32-33 split proinsulin, which is interpreted as a sign of beta cell dysfunction.
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Fetal nutrition and cardiovascular disease in adult life
David J.P. Barker,Peter D. Gluckman,Keith M. Godfrey,Jane E. Harding,Julie A. Owens,J. S. Robinson +5 more
TL;DR: This paper shows how fetal undernutrition at different stages of gestation can be linked to these patterns of early growth in babies who are small at birth or during infancy.
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