Journal Article10.1042/CS0950115
In utero programming of chronic disease
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TL;DR: This review examines the evidence linking these diseases to fetal undernutrition and provides an overview of previous studies in this area.
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Abstract: 1 Many human fetuses have to adapt to a limited supply of nutrients In doing so they permanently change their structure and metabolism 2 These 'programmed' changes may be the origins of a number of diseases in later life, including coronary heart disease and the related disorders stroke, diabetes and hypertension 3 This review examines the evidence linking these diseases to fetal undernutrition and provides an overview of previous studies in this area
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A Comparison of Preterm Birth Rate and Growth from Birth to 18 Years Old between in Vitro Fertilization and Spontaneous Conception of Twins.
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References
Prognostic Implications of Echocardiographically Determined Left Ventricular Mass in the Framingham Heart Study
TL;DR: The estimation of left ventricular mass by echocardiography offers prognostic information beyond that provided by the evaluation of traditional cardiovascular risk factors, and it is concluded that an increase in left Ventricular mass predicts a higher incidence of clinical events, including death, attributable to cardiovascular disease.
5.6K
Sick individuals and sick populations
TL;DR: Aetiology confronts two distinct issues: the determinant of individual cases, and the determinants of incidence rate: if exposure to a necessary agent is homogeneous within a population, then case/control and cohort methods will fail to detect it.
Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales.
David J.P. Barker,Clive Osmond +1 more
TL;DR: Although the rise in ischaemic heart disease in England and Wales has been associated with increasing prosperity, mortality rates are highest in the least affluent areas.
2.8K
Fetal and infant growth and impaired glucose tolerance at age 64.
C. N. Hales,David J.P. Barker,Penelope M.S. Clark,Lorna Cox,Caroline H.D. Fall,Clive Osmond,P D Winter +6 more
TL;DR: Reduced growth in early life is strongly linked with impaired glucose tolerance and non-insulin dependent diabetes and reduced early growth is also related to a raised plasma concentration of 32-33 split proinsulin, which is interpreted as a sign of beta cell dysfunction.
2.8K
Fetal nutrition and cardiovascular disease in adult life
David J.P. Barker,Peter D. Gluckman,Keith M. Godfrey,Jane E. Harding,Julie A. Owens,J. S. Robinson +5 more
TL;DR: This paper shows how fetal undernutrition at different stages of gestation can be linked to these patterns of early growth in babies who are small at birth or during infancy.
2.8K