Journal Article10.1042/CS0950115
In utero programming of chronic disease
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TL;DR: This review examines the evidence linking these diseases to fetal undernutrition and provides an overview of previous studies in this area.
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Abstract: 1 Many human fetuses have to adapt to a limited supply of nutrients In doing so they permanently change their structure and metabolism 2 These 'programmed' changes may be the origins of a number of diseases in later life, including coronary heart disease and the related disorders stroke, diabetes and hypertension 3 This review examines the evidence linking these diseases to fetal undernutrition and provides an overview of previous studies in this area
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Citations
Maternal Beslenmenin Yavrular Üzerine Etkileri: Fetal Programlama ve Epigenetik Mekanizmalar
Sabriye Arslan,Hilal Yildiran +1 more
TL;DR: In this review, epigenetic mechanisms, one of the mechanisms underlying the effects of maternal nutrition on fetal programming, were discussed in the light of data obtained from epidemiological studies and animal models.
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Maternal–fetal medicine – How can we practically connect the “M” to the “F”?
Moshe Hod,Nicky Lieberman +1 more
TL;DR: This article addresses the lack of communication between the two subspecialties of maternal and fetal medicine and proposes a resolution that will bridge the discrepancies by proposing to connect the leading hypotheses in MFM and in fetal medicine to those in maternal medicine.
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Evidence-based interventions in low- and middle-income countries: the tigress awakens.
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Premature aging of the lungs of the offspring induced by maternal nicotine exposure during gestation and lactation: protective effects of tomato juice
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David J.P. Barker,Clive Osmond +1 more
TL;DR: Although the rise in ischaemic heart disease in England and Wales has been associated with increasing prosperity, mortality rates are highest in the least affluent areas.
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C. N. Hales,David J.P. Barker,Penelope M.S. Clark,Lorna Cox,Caroline H.D. Fall,Clive Osmond,P D Winter +6 more
TL;DR: Reduced growth in early life is strongly linked with impaired glucose tolerance and non-insulin dependent diabetes and reduced early growth is also related to a raised plasma concentration of 32-33 split proinsulin, which is interpreted as a sign of beta cell dysfunction.
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David J.P. Barker,Peter D. Gluckman,Keith M. Godfrey,Jane E. Harding,Julie A. Owens,J. S. Robinson +5 more
TL;DR: This paper shows how fetal undernutrition at different stages of gestation can be linked to these patterns of early growth in babies who are small at birth or during infancy.
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