Journal Article10.1002/PBC.28383
Improvement of overall survival in the Collaborative Wilms Tumour Africa Project.
George Chagaluka,Vivian Paintsil,Lorna Renner,Janna Weijers,Inam Chitsike,Eric Borgstein,Steve Kamiza,Glenn M. Afungchwi,Francine Kouya,Peter Hesseling,Elizabeth Molyneux,Trijn Israels +11 more
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TL;DR: The Collaborative Wilms Tumour Africa Project implemented an adapted WT treatment guideline in six centres in sub‐Saharan Africa to describe abandonment of treatment, death during treatment, event‐free survival (EFS) and relapse following implementation.
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Abstract: INTRODUCTION The Collaborative Wilms Tumour (WT) Africa Project implemented an adapted WT treatment guideline in six centres in sub-Saharan Africa. The primary objectives were to describe abandonment of treatment, death during treatment, event-free survival (EFS) and relapse following implementation. An exploratory objective was to compare outcomes with the baseline evaluation, a historical cohort preceding implementation. METHODS The Collaborative WT Africa Project is a multi-centre prospective clinical trial that began in 2014. Funding was distributed to all participating centres and used to cover treatment, travel and other associated costs for patients. Patient characteristics, tumour characteristics and events were described. RESULTS In total, 201 WT patients were included. Two-year EFS was 49.9 ± 3.8% when abandonment of treatment was considered an event. Relapse of disease occurred in 21% (42 of 201) of all included patients and in 26% (42 of 161) of those who had a nephrectomy. Programme implementation was associated with significantly higher survival without evidence of disease at the end of treatment (52% vs 68.5%, P = .002), significantly reduced abandonment of treatment (23% vs 12%, P = .009) and fewer deaths during treatment (21% vs 13%, P = .06). CONCLUSION This collaborative implementation of an adapted WT treatment guideline, using relatively simple and low-cost interventions, was feasible. Two-year EFS was almost 50%. In addition, a significant decrease in treatment abandonment and an increase in survival at the end of treatment were observed compared to a pre-implementation cohort. Future work should focus on decreasing deaths during treatment and will include enhancing supportive care.
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Citations
Prognostic Factors for Wilms Tumor Recurrence: A Review of the Literature
Alissa Groenendijk,Filippo Spreafico,Ronald R. de Krijger,Jarno Drost,Jesper Brok,Daniela Perotti,Harm van Tinteren,Rajkumar Venkatramani,J. Godzinski,Christian Rübe,James I. Geller,Norbert Graf,Marry M. van den Heuvel-Eibrink,Annelies M. C. Mavinkurve-Groothuis +13 more
TL;DR: A comprehensive overview of published prognostic variables for Wilms tumor recurrence can be found in this paper, including patient-, tumor-and treatment-related characteristics to geographic and socioeconomic factors.
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International Comparisons of Clinical Demographics and Outcomes in the International Society of Pediatric Oncology Wilms Tumor 2001 Trial and Study
Joaquim Caetano de Aguirre-Neto,Beatriz de Camargo,Harm van Tinteren,Christophe Bergeron,Jesper Brok,Gema L. Ramírez-Villar,Arnauld Verschuur,Rhoikos Furtwängler,Lisa Howell,Daniel Saunders,O.E. Olsen,Aurore Coulomb,Christian Vokuhl,Jan Godzinski,Ann Smeets,Gordan M. Vujanic,Marry M. van den Heuvel-Eibrink,Norbert Graf,Kathy Pritchard-Jones +18 more
TL;DR: International benchmarking of survival rates from WT within a large trial/study database has demonstrated statistically significant differences and clinical interpretation should take account of variation in tumor stage but also treatment factors.
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Pediatric renal tumor epidemiology: Global perspectives, progress, and challenges
Jaime Libes,Janna A. Hol,Joaquim Caetano Aguirre Neto,Kelly Vallance,Harm van Tinteren,Daniel J. Benedetti,Gema Villar,Catriona Duncan,Peter F. Ehrlich +8 more
TL;DR: In this article , the authors reviewed the global epidemiology of pediatric renal tumors, including key consortium and global studies, and identified current knowledge gaps and challenges facing both high and low middle-incomes countries.
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Advances in the clinical management of high‐risk Wilms tumors
Michael V. Ortiz,Christa Koenig,Amy E. Armstrong,Jesper Brok,Beatriz de Camargo,Annelies M. C. Mavinkurve-Groothuis,T. B. V. Herrera,Rajkumar Venkatramani,Andrew D. Woods,Jeffrey S. Dome,Filippo Spreafico +10 more
TL;DR: In this paper , the authors introduced the authors' view of the historical and current approach to the classification and treatment of high-risk Wilms tumor (WT) patients, including newly diagnosed metastatic blastemal-type or diffuse anaplastic histology, those who relapse after having been initially treated with three or more different chemotherapeutics, or those who relapsed more than once.
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Evidence‐based surgical guidelines for treating children with Wilms tumor in low‐resource settings
Abdelhafeez H. Abdelhafeez,Tea Reljic,Ambuj Kumar,Tahmina Banu,Sharon Cox,Andrew M. Davidoff,Ahmed Elgendy,Khalil Ghandour,J. Ted Gerstle,Jonathan Karpelowsky,Sue C. Kaste,Nahla Kechiche,Natia Esiashvili,Abdulrasheed A Nasir,A Ngongola,Jin Marollano,A. Moreno,Arlene Muzira,Jeannette Parkes,Lily J. Saldaña,Jaime Shalkow,Gordan M. Vujanic,Thelma Velasquez,Kokila Lakhoo,Sheena Mukkada,Simone de Campos Vieira Abib +25 more
TL;DR: Survival of Wilms tumor (WT) is > 90% in high‐resource settings but < 30% in low‐ resource settings, but a local control strategy is crucial to improving outcomes.
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TL;DR: Childhood cancer burden has been shifted toward low- and middle-income countries and, for that reason, global initiatives directed at pediatric cancer care and control are needed.
Advances in Wilms Tumor Treatment and Biology: Progress Through International Collaboration
Jeffrey S. Dome,Norbert Graf,James I. Geller,Conrad V. Fernandez,Elizabeth Mullen,Filippo Spreafico,Marry M. van den Heuvel-Eibrink,Kathy Pritchard-Jones +7 more
TL;DR: An overview of the Children's oncology Group and International Society of Pediatric Oncology approaches to WT focuses on four subgroups (stage IV, initially inoperable, bilateral, and relapsed WT) for which international collaboration is pressing and biologic insights resulting from collaborative laboratory research are discussed.
Establishment of a pediatric oncology program and outcomes of childhood acute lymphoblastic leukemia in a resource-poor area.
Scott C. Howard,Marcia Pedrosa,Mecneide Mendes Lins,Arli Pedrosa,Ching-Hon Pui,Raul C. Ribeiro,Francisco Pedrosa +6 more
TL;DR: Treatment of childhood ALL in a dedicated pediatric oncology unit using a comprehensive multidisciplinary team approach, protocol-based therapy, and local support and funding is associated with improved outcomes in a resource-poor area.
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The My Child Matters programme: effect of public–private partnerships on paediatric cancer care in low-income and middle-income countries
Scott C. Howard,Alia Zaidi,Xueyuan Cao,Olivier Weil,Pierre Bey,Catherine Patte,Angélica Samudio,Laurie Haddad,Catherine G. Lam,Claude Moreira,Augusto Pereira,Mhamed Harif,Laila Hessissen,Salma Choudhury,Ligia Fu,Miguela A. Caniza,Julius Lecciones,Fousseyni Traoré,Raul C. Ribeiro,Anne Gagnepain-Lacheteau +19 more
TL;DR: The My Child Matters programme has catalysed improvements in cancer care and has complemented the efforts of government, civil society, and the private sector to sustain and scale improvements in health care to a national level.
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SIOP PODC: clinical guidelines for the management of children with Wilms tumour in a low income setting.
Trijn Israels,Trijn Israels,Claude Moreira,Trish Scanlan,Liz Molyneux,Sam Kampondeni,Peter Hesseling,Hugo A. Heij,Eric Borgstein,Gordan M. Vujanic,Kathy Pritchard-Jones,Larry G. P. Hadley +11 more
TL;DR: Recommendations specific for Wilms tumour care include diagnostic procedures with emphasis on the role of ultrasonography, preoperative chemotherapy with a reduced dosage for malnourished children and postoperative chemotherapy based on surgical staging.
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