Journal Article10.1016/0167-4781(95)00145-7
Improved leishmanicidal effect of phosphorotioate antisense oligonucleotides by LDL-mediated delivery
Rakesh Mishra,Catherine Moreau,Claude Ramazeilles,Serge Moreau,Jacques Bonnet,Jean-Jacques Toulmé +5 more
232
TL;DR: A 2-fold increase in the antisense effect of LDL-oligonucleotide complexes was observed suggesting that alternative (unregulated) scavenger receptor can be used for more efficient delivery of antisense oligonucleotides into macrophages.
read more
About: This article is published in Biochimica et Biophysica Acta. The article was published on 07 Nov 1995. The article focuses on the topics: Oligonucleotide & Scavenger receptor.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Patent
2'-o-aminoethyloxyethyl-modified oligonucleotides
Muthiah Manoharan,Phillip Dan Cook +1 more
- 06 Aug 1999
TL;DR: In this paper, 2-O-modified ribosyl nucleosides and modified oligomeric compounds containing such nucleosidic monomers are disclosed, which have increased binding affinity as shown by molecular modelling experiments.
122
Patent
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
Stephane Bancel,Tirtha Chakraborty,Antonin de Fougerolles,Sayda M. Elbashir,Matthias John,Atanu Roy,Susan Whoriskey,Kristy M. Wood,Paul Hatala,Jason P. Schrum,Kenechi Ejebe,Jeff Lynn Ellsworth,Justin Guild +12 more
- 09 Mar 2013
TL;DR: In this article, the polypeptide of the invention comprises a first region of linked nucleosides encoding a poly peptide of interest selected from the group consisting of specific sequences, a 5" UTR, a 3' UTR and a 5' cap and a polyA tail.
114
Patent
iRNA AGENTS TARGETING VEGF
Antonin de Fougerolles,Maria Frank-Kamenetsky,Muthiah Manoharan,Kallanthottathil G. Rajeev,Philipp Hadwiger +4 more
- 11 Mar 2005
TL;DR: The features of the present invention relate to compounds, compositions and methods useful for modulating the expression of vascular endothelial growth factor (VEGF), such as by the mechanism of RNA interference (RNAi).
113
Patent
In vivo production of proteins
Stephane Bancel,Tirtha Chakraborty,Antonin de Fougerolles,Sayda Elbashir,Matthias John,Atanu Roy,Susan Whoriskey,Kristy M. Wood,Paul Hatala,Jason P. Schrum,Kenechi Ejebe,Jeff Lynn Ellsworth,Justin Guild +12 more
- 15 Mar 2013
TL;DR: In this article, the authors describe compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues.
113
Patent
Ligand-conjugated oligomeric compounds
Muthiah Manoharan
- 15 Jun 2000
TL;DR: In this article, ligand-conjugated oligomeric compounds are described wherein ligands are conjugated to one or more sites on an oligomerial compound including the 2'-, 3'-, 5'-, nucleobase and internucleotide linkage sites.
111
References
The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
TL;DR: The relatively low density of the lipoproteins was utilized by Lindgren, Elliott, and Gofman to separate them from the other serum proteins by ultracentrifugal flotation, and quantitation was subsequently performed by refractometric methods in the analytical ultracentRifuge.
•Book
Antisense Research and Applications
Sudhir Agrawal,Stanley T. Crooke +1 more
- 27 May 1993
TL;DR: Pharmacological Effects of Antisense Oligonucleotides to Protein Kinase C-a and C-raf Kinase: Rationale and Clinical Experience in Patients with Solid Tumors and Nucleic Acid Therapeutics for Human Leukemia.
1.5K
Antisense oligonucleotides as therapeutic agents--is the bullet really magical?
Cy A. Stein,Yung-Chi Cheng +1 more
TL;DR: The potential use of phosphorothioate oligos as inhibitors of viral replication is highlighted and these are examples of oligos that are being considered for clinical therapeutic trials and meet some, but not all, of these criteria.
1.5K
Specific regulation of gene expression by antisense, sense and antigene nucleic acids.
TL;DR: The regula t ion of gene express ion in l iving organisms rests main ly upon the recogniT ion of nucleic acid base sequences by pro te ins, but nucleic acids can also p lay a role.
855
The automated synthesis of sulfur-containing oligodeoxyribonucleotides using 3H-1,2-benzodithiol-3-one 1,1-dioxide as a sulfur-transfer reagent
TL;DR: Several polysulfides were tested as potential sulfur-transfer reagents during the automated synthesis of oligodeoxyribonucleoside phosphorothioates via the deoxyriboenucleosides phosphoramidite approach as discussed by the authors, and thiosulfonate 3H-1,2-benzodithiol-3-one 1,1-dioxide (12) was particularly efficient as a sulfurizing reagent
309