Journal Article10.1182/BLOOD.V88.7.2775.BLOODJOURNAL8872775
Improved immune reconstitution after allotransplantation of peripheral blood stem cells instead of bone marrow.
382
TL;DR: The question of whether the documented improved in vitro immune competence after PBSCT is associated with a lower incidence of infectious complications in vivo still needs further study.
read more
About: This article is published in Blood. The article was published on 01 Oct 1996. The article focuses on the topics: Bone marrow & Immune system.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
The Biology and Clinical Uses of Blood Stem Cells
TL;DR: It seems more than ever likely that blood-derived stem cells will replace marrow for many indications, according to recent data from the International Bone Marrow Transplant Registry (IBMTR).
751
Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation.
Jan Storek,Monja A. Dawson,Barry E. Storer,Terry Stevens-Ayers,David G. Maloney,Kieren A. Marr,Robert P. Witherspoon,William I. Bensinger,Mary E.D. Flowers,Paul J. Martin,Rainer Storb,Frederick R. Appelbaum,Michael Boeckh +12 more
TL;DR: Blood stem cell recipients have higher lymphocyte-subset counts and this appears to result in fewer infections, as studied in 115 patients randomly assigned to receive either allogeneic marrow or filgrastim-mobilized blood stem cell transplantation.
408
Peripheral blood stem cell versus bone marrow allotransplantation: does the source of hematopoietic stem cells matter?
Martin Korbling,Paolo Anderlini +1 more
TL;DR: The various stem cell sources differ in their reconstitutive and immunogenic characteristics, which are based on the proportion of early pluripotent and self-renewing stem cells to lineage-committed late progenitor cells and on the number and characteristics of accompanying "accessory cells" contained in stem cell allografts.
387
Reconstitution of the immune system after hematopoietic stem cell transplantation in humans
Jan Storek,Michelle Geddes,Faisal Khan,Bertrand Huard,Claudine Helg,Yves Chalandon,Jakob Passweg,Eddy Roosnek +7 more
TL;DR: In conclusion, stem cell transplantation is associated with a severe immune deficiency and B- and T-cell counts normalize during the first months after transplantation, but in particular, T- cell immunity may remain impaired for years.
Reconstitution of the T-Cell Compartment After Bone Marrow Transplantation: Restoration of the Repertoire by Thymic Emigrants
Florence Dumont-Girard,E Roux,R. A. W. Van Lier,Geoff Hale,C Helg,B Chapuis,Michel Starobinski,E Roosnek +7 more
TL;DR: In this paper, the authors studied the reconstitution of the T-cell compartment after bone marrow transplantation (BMT) in five patients who received a graft-versus-host disease (GVHD) prophylaxis consisting of methotrexate, cyclosporin, and 10 daily injections (day -4 to day +5) of Campath-1G.
223
References
Age-related changes in human blood lymphocyte subpopulations.
Feza Erkeller-Yuksel,Véronique Deneys,B. Yuksel,I. Hannet,F. Hulstaert,C. Hamilton,H. Mackinnon,L. Turner Stokes,V. Munhyeshuli,F. Vanlangendonck,M. De Bruyere,B.A. Bach,Peter M. Lydyard +12 more
TL;DR: Comparisons among age groups from newborn infants through adults reveal progressive declines in the absolute numbers of leukocytes, total lymphocytes, and T, B, and natural killer cells.
464
G-csf-mobilized peripheral blood progenitor cells for allogeneic transplantation : safety, kinetics of mobilization, and composition of the graft
Peter Dreger,Torsten Haferlach,V Eckstein,S Jacobs,M Suttorp,Helmut Löffler,Wolfgang Müller-Ruchholtz,Norbert Schmitz +7 more
TL;DR: In conclusion, sufficient amounts of PBPC capable of restoring haemopoiesis in allogeneic recipients can be mobilized safely by administration of G‐CSF and the cellular composition of the resulting PBPC grafts is analysed.
350