Impaired peripheral blood T-follicular helper cell function in HIV-infected nonresponders to the 2009 H1N1/09 vaccine.
Suresh Pallikkuth,Anita Parmigiani,Sandra Y. Silva,Varghese K. George,Margaret A. Fischl,Rajendra Pahwa,Savita Pahwa +6 more
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TL;DR: Investigating pTFH cells in 25 HIV-infected patients on antiretroviral therapy may provide additional insight into cellular determinants of vaccine-induced Ab response, which may have relevance for vaccine design.
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About: This article is published in Blood. The article was published on 02 Aug 2012. and is currently open access. The article focuses on the topics: Interleukin 21 & Germinal center.
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Citations
Induction of peripheral blood T follicular helper cells expressing ICOS correlates with antibody response to hepatitis B vaccination
Mingluan Xing,Yonghui Feng,Jun Yao,Huakun Lv,Yongdi Chen,Hanqing He,Zhifang Wang,Chonggao Hu,Xiaoming Lou +8 more
TL;DR: Analysis of ICOS+pTFH cells represents a novel cellular determinant of the hepatitis B vaccine–induced humoral immune response, which may have relevance for design of hepatitis B vaccination.
Premature immune senescence during HIV-1 vertical infection relates with response to influenza vaccination.
Alberto Cagigi,Stefano Rinaldi,Angela Di Martino,Emma Concetta Manno,Paola Zangari,Angela Aquilani,Nicola Cotugno,Luciana Nicolosi,Alberto Villani,Stefania Bernardi,Isabella Donatelli,Savita Pahwa,Paolo Rossi,Paolo Palma +13 more
HIV infection alters SARS-CoV-2 responsive immune parameters but not clinical outcomes in COVID-19 disease
Farina Karim,Inbal Gazy,Sandile Cele,Yenzekile Zungu,Robert Krause,Mallory Bernstein,Yashica Ganga,Hylton Errol Rodel,Ntombifuthi Mthabela,Matilda Mazibuko,Khadija Khan,Daniel M. Muema,Dirhona Ramjit,Gila Lustig,Thumbi Ndung'u,Willem A. Hanekom,Bernadett I Gosnell,Commit-Kzn Team,Emily B. Wong,Tulio de Oliveira,Mahomed-Yunus S. Moosa,Alasdair Leslie,Henrik N. Kløverpris,Henrik N. Kløverpris,Alex Sigal,Alex Sigal +25 more
TL;DR: The impact of HIV on the immune response to SARS-CoV-2 was investigated using longitudinal samples from 124 participants from KwaZulu-Natal, South Africa, an area of extremely high HIV prevalence and likely reflects the heterogeneity of an effective COVID-19 immune response.
HIV status alters disease severity and immune cell responses in beta variant SARS-CoV-2 infection wave.
Farina Karim,Inbal Gazy,Sandile Cele,Yenzekile Zungu,Robert Krause,Mallory Bernstein,Khadija Khan,Yashica Ganga,Hylton Errol Rodel,Ntombifuthi Mthabela,Matilda Mazibuko,Daniel M. Muema,Dirhona Ramjit,Thumbi Ndung'u,Willem A. Hanekom,Bernadett I Gosnell,Richard J Lessells,Emily B. Wong,Tulio de Oliveira,Yunus Moosa,Gil Lustig,Alasdair Leslie,Henrik N. Kløverpris,Alex Sigal +23 more
TL;DR: In this article, the authors analyzed disease severity and immune cell changes during and after SARS-CoV-2 infection in 236 participants from South Africa, of which 39% were people living with HIV (PLWH), during the first and second (beta dominated) infection waves.
Impact of Corticosteroids on the Proportions of Circulating Tfh Cell Subsets in Patients With Systemic Lupus Erythematous
TL;DR: Corticosteroids treatment not only down-regulated the proportion of circulating Tfh cells, but also altered the distribution of T fh subsets in vivo and in vitro.
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Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
TL;DR: This review addresses the heterogeneity of TCM and TEM, their differentiation stages, and the current models for their generation and maintenance in humans and mice.
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TL;DR: This review discusses recent progress and areas of uncertainty or disagreement in the literature, and debates the developmental relationship between T(FH) cells and other CD4 T cell subsets (Th1, Th2, Th17, iTreg).
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CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract
Jason M. Brenchley,Timothy W. Schacker,Laura E. Ruff,David Price,Jodie H. Taylor,Gregory J. Beilman,Phuong L. Nguyen,Alexander Khoruts,Matthew Larson,Ashley T. Haase,Daniel C. Douek +10 more
TL;DR: The nature and extent of CD4+ T cell depletion in lymphoid tissue is defined and mechanisms of profound depletion of specific T cell subsets related to elimination of CCR5+ CD4- T cell targets and disruption of T cell homeostasis that accompanies chronic immune activation are pointed to.
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