Journal Article10.2337/DIAB.29.4.309
Impaired Granulocyte Adherence in Mildly Diabetic Patients: Effects of Tolazamide Treatment
J D Bagdade,E Walters +1 more
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TL;DR: Results of this study indicate that, even in some mildly diabetic patients, a reduction in granulocyte is found, similar to that found in insulin-dependent diabetics, which may impair the inflammatory response.
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Abstract: Granulocyte adherence in 10 of 15 untreated asymptomatic hyperglycemic diabetic outpatients (mean fasting glucose +/- SEM, 289 +/- 16 mg/100 ml) was 62 +/- 7% of control values. After treatment (2--4 wk) with tolazamide (500 mg daily), adherence to the nylon fiber columns employed in this study returned to control levels in the seven patients whose fasting glucose levels fell, (mean, 192 +/- 16 mg/100 ml) and deteriorated in the three in whom fasting hyperglycemia worsened. Results of this study indicate that, even in some mildly diabetic patients, a reduction in granulocyte adherence similar to that found in insulin-dependent diabetics may impair the inflammatory response.
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Citations
Making health care safer: a critical analysis of patient safety practices.
Kaveh G. Shojania,Bradford W Duncan,Kathryn M. McDonald,Robert M. Wachter,Amy J. Markowitz +4 more
- 01 Jan 2001
TL;DR: This project aimed to collect and critically review the existing evidence on practices relevant to improving patient safety and identify practices with the strongest supporting evidence that decrease the risks associated with hospitalization, critical care, or surgery.
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Immune dysfunction in patients with diabetes mellitus (DM)
TL;DR: Patients with diabetes mellitus (DM) have infections more often than those without DM and an increased adherence of microorganisms to diabetic compared to nondiabetic cells has been described for Candida albicans.
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Superoxide Dismutase in Diabetic Polymorphonuclear Leukocytes
TL;DR: The level of Superoxide anion was found to be significantly elevated in polymorphonuclear leukocytes (PMNL) from diabetic subjects as compared with those from normal subjects, and PMNL obtained from insulin-treated diabetic patients showed considerable alleviation of SOD levels.
99
Inpatient management of diabetes mellitus.
TL;DR: This work proposes guidelines and a framework for improving the glycemic control of hospitalized patients and shows improved outcomes with intensive glucose management in acutely ill patients.
74
References
Chemotaxis of polymorphonuclear leukocytes from patients with diabetes mellitus.
Alastair G. Mowat,John Baum +1 more
TL;DR: The mean chemotactic index in 31 patients with diabetes mellitus was significantly less than that in 31 matched controls, and it is suggested that this defect in the chemotaxis of diabetic leukocytes could contribute to increased infections in these patients.
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Impaired Leukocyte Function in Patients with Poorly Controlled Diabetes
TL;DR: PMN function may be impaired during periods of poor diabetes control, as has been shown previously in ketoacidosis, and hyperglycemia or a closely related factor may contribute to the defect.
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Inhibition of Granulocyte Adherence by Ethanol, Prednisone, and Aspirin, Measured with an Assay System
TL;DR: In all volunteers receiving 40 mg of prednisone or 1.2 g of aspirin, impaired adherence developed, suggesting that glucocorticoids and salicylates may affect adherence in vivo by inducing an inhibitor.
500
Impaired Granulocyte Adherence: A Reversible Defect in Host Defense in Patients with Poorly Controlled Diabetes
TL;DR: Granulocyte adherence may also be impaired in poorly controlled diabetic patients and a defect of this type may compromise the normal inflammatory response in some diabetics and impair their capacity to resist infection.
286
•Journal Article
Neutrophil dysfunction in diabetes mellitus.
TL;DR: The neutrophil bactericidal capacity of 31 patients with diabetes mellitus in a nonketoacidotic state, including 21 without infections and 10 with recurrent infections, were evaluated and all 3 patients with a combined defect had severe bacterial infections.
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