Immunotherapy Bridge 2016 and Melanoma Bridge 2016: meeting abstracts
Vera Hirsh,Sandro Pignata,Melissa Bersanelli,Letizia Gnetti,Cinzia Azzoni,Lorena Bottarelli,Donatello Gasparro,Francesco Leonardi,Enrico Maria Silini,Sebastiano Buti,Erik Wennerberg,Aránzazu Mediero,Bruce N. Cronstein,Silvia C. Formenti,Sandra Demaria,Claire Vanpouille-Box,Karsten A. Pilones,Nils Rudqvist,Julie M. Diamond,Zachary S. Morris,Emily I. Guy,David M. Francis,Monica M. Gressett,Eric A. Armstrong,Shyhmin Huang,Stephen D. Gilles,Alan J. Korman,Jacquelyn A. Hank,Anna Hoefges,Alexander L. Rakhmilevich,Paul M. Harari,Paul M. Sondel,Yared Hailemichael,Willem W. Overwijk,Per thor Straten,Alessandro Lugli,Heather Dawson,Annika Blank,Inti Zlobec,Luigi Fattore,Susan Costantini,Mario Acunzo,Giulia Romano,Giovanni Nigita,Alessandro Laganà,Debora Malpicci,Ciro Francesco Ruggiero,Maria Elena Pisanu,Alessia Noto,Claudia De Vitis,Carlo M. Croce,Paolo A. Ascierto,Rita Mancini,Gennaro Ciliberto,Michael A. Postow,Jason J. Luke,David F. Stroncek,Luciano Castiello,Wenjing Chen,Ping Jin,Jiaqiang Ren,Marianna Sabatino,Soldano Ferrone,Connie P.M. Duong,Connie P.M. Duong,Marie Vétizou,Marie Vétizou,Laurence Zitvogel,Marcella Occelli,Carolina Cauchi,Grazia Sciancalepore,Cristiana Lo Nigro,Michela Rovera,Chiara Varamo,Daniela Vivenza,Zelda Seia,Stefania Palazzini,Fabiana Errico,Davide Basso,Laura Quaranta,Giuseppe Forte,Fulvio Lavagna,Silvia Violante,Paolo Bosio,Laura Lattanzio,Marco Carlo Merlano,Duane Moogk,Shi Zhong,Zhiya Yu,Ivan Liadi,William Rittase,Victoria Fang,Janna Dougherty,Arianne Perez-Garcia,Iman Osman,Cheng Zhu,Navin Varadarajan,Nicholas P. Restifo,Alan B. Frey,Michelle Krogsgaard,Timea Balatoni,Anita Moho,Tímea Sebestyén,Anita Varga,Judit Oláh,Zsuzsanna Lengyel,Gabriella Emri,Gabriella Liszkay,Andrea Ladányi,Beatrice Polini,Stefano Fogli,Sara Carpi,Barbara Pardini,Alessio Naccarati,Nevio Dubbini,Maria Cristina Breschi,Antonella Romanini,Paola Nieri,Francesca Morgese,Davide Soldato,Silvia Pagliaretta,Riccardo Giampieri,Donatella Brancorsini,Silvia Rinaldi,Mariangela Torniai,Anna Campanati,Giulia Ganzetti,Annamaria Offidani,Alfredo Giacchetti,Giuseppe Ricotti,Agnese Savini,Azzurra Onofri,Francesca Bianchi,Rossana Berardi,Giovanna Galdo,Gianfranco Orlandino,Salvatore Serio,Domenico Massariello,Tommaso Fabrizio,Valentina Montagnani,Matteo Benelli,Alessandro Apollo,Chiara Pescucci,Danilo Licastro,Carmelo Urso,Gianni Gerlini,Lorenzo Borgognoni,Lucio Luzzatto,Barbara Stecca,Elisabetta Gambale,Camilla Tinari,Alberto Quinzii,Alessio Cortellini,Consiglia Carella,Michele De Tursi,Adele Emanuela De Francesco,Mariarosanna De Fina,Maria Cristina Zito,Maria Dezia Bisceglia,Stefania Esposito,Giuseppina Fersini,Silvana Morello,Claudia Sorrentino,Aldo Pinto,Antonella Di Sarno,Antonella Bianco,Carmine D’Aniello,Francesca Andreozzi,Lucia Festina,Vito Vanella,Vincenzo Montesarchio,Beatrix Kotlan,Maria Godeny,Farkas Emil,Laszlo S. Toth,Szabolcs Horvath,Klara Eles,Akos Savolt,Andras Szollar,Miklos Kasler,Daniel Yiu,Fabio Grizzi,Federica Patrinicola,Maurizio Chiriva-Internati,S. Motta,Marcello Monti,Lavinia Benini,Stefano Ugel,Sara Cingarlini,Alessandra Fiore,Elisabetta Grego,Giampaolo Tortora,Vincenzo Bronte,Luca Tondulli,Gianluca Di Monta,Corrado Caracò,Ugo Marone,Lucia Festino,Nicola Mozzillo +198 more
TL;DR: The Immunotherapy Bridge 2016: Keynote speaker presentations Immunotherapy beyond melanoma and beyond applies to the data made available in this article, unless otherwise stated.
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Abstract: © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Immunotherapy Bridge 2016: Keynote speaker presentations Immunotherapy beyond melanoma
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CD103+ Tumor-Resident CD8+ T Cells Are Associated with Improved Survival in Immunotherapy-Naïve Melanoma Patients and Expand Significantly During Anti–PD-1 Treatment
Jarem Edwards,James S. Wilmott,Jason Madore,Tuba N. Gide,Camelia Quek,Annie Tasker,Angela Ferguson,Jinbiao Chen,Rehana Hewavisenti,Peter Hersey,Thomas Gebhardt,Wolfgang Weninger,Warwick J. Britton,Robyn P. M. Saw,Robyn P. M. Saw,John F. Thompson,John F. Thompson,Alexander M. Menzies,Alexander M. Menzies,Georgina V. Long,Georgina V. Long,Richard A. Scolyer,Richard A. Scolyer,Umaimainthan Palendira +23 more
TL;DR: Tumor-resident CD8-cell numbers are more prognostic than total CD8+ T cells in metastatic melanoma and are likely to initiate response to anti–PD-1 and anti–LAG-3 treatments, and it is proposed that the immune profile of these cells prior to treatment could inform strategies for immune checkpoint blockade.
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TL;DR: Nivolumab was associated with significant improvements in overall survival and progression-free survival, as compared with dacarbazine, among previously untreated patients who had metastatic melanoma without a BRAF mutation.
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