Journal Article10.1016/J.ACTBIO.2021.01.025
Immunomodulatory biomaterials and their application in therapies for chronic inflammation-related diseases.
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TL;DR: In this article, the influence of different types of biomaterials such as nanoparticles, hydrogels and scaffolds on the immune cells and the modification of immune-responsive factors such as reactive oxygen species (ROS), cytokines, chemokines, enzymes, and metalloproteinases in tissue microenvironment are summarized.
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About: This article is published in Acta Biomaterialia. The article was published on 15 Mar 2021. The article focuses on the topics: Immune system & Regeneration (biology).
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A reactive oxygen species-responsive hydrogel encapsulated with bone marrow derived stem cells promotes repair and regeneration of spinal cord injury
Ziming Li,Tengfei Zhao,Jie Ding,Haochen Gu,Qiaoxuan Wang,Yifan Wang,Deteng Zhang,Changyou Gao +7 more
TL;DR: In this article , a thioketal-containing and ROS-scavenging hydrogel was prepared for encapsulation of the bone marrow derived mesenchymal stem cells (BMSCs), which promoted the neurogenesis and axon regeneration by scavenging the overproduced reactive oxygen species (ROS) produced by the infiltrated inflammatory immune cells and released to the extracellular microenvironment, leading to widespread apoptosis of the neuron cells, glial and oligodendroctyes.
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Biocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone
TL;DR: This essay shows that there is solid scientific evidence of the existence of bioactivity mechanisms that are associated with some types of biomaterials, especially when the material is modified in a manner designed to specifically induce that activity.
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Mussel-inspired collagen-hyaluronic acid composite scaffold with excellent antioxidant properties and sustained release of a growth factor for enhancing diabetic wound healing
Yong Wang,Li Chen,Danyang Ren,Zi-Xuan Feng,Li-Yun Zhang,Yuhu Zhong,Ming Jin,Fang Xu,Chun-Yan Feng,Yong-Zhong Du,Wei-Qiang Tan +10 more
TL;DR: In this paper , a mussel-inspired bioactive scaffold consisting mainly of collagen and hyaluronic acid, which are natural biopolymer materials contained in human tissues, was used in clinical diabetic wound treatment as a low-cost and easily available wound dressing.
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