Immunomodulatory biomaterials and their application in therapies for chronic inflammation-related diseases.

TL;DR: In this paper, a review article summarizing the immunomodulatory effects of BGs for tissue repair and regeneration is presented, highlighting the strategies employed to modulate macrophage responses for enhancing tissue regeneration, including incorporation of active ions, surface functionalization, and controlled release of immunOModulatory agents.

TL;DR: In this article , a thioketal-containing and ROS-scavenging hydrogel was prepared for encapsulation of the bone marrow derived mesenchymal stem cells (BMSCs), which promoted the neurogenesis and axon regeneration by scavenging the overproduced reactive oxygen species (ROS) produced by the infiltrated inflammatory immune cells and released to the extracellular microenvironment, leading to widespread apoptosis of the neuron cells, glial and oligodendroctyes.

TL;DR: This essay shows that there is solid scientific evidence of the existence of bioactivity mechanisms that are associated with some types of biomaterials, especially when the material is modified in a manner designed to specifically induce that activity.

TL;DR: In this paper , a mussel-inspired bioactive scaffold consisting mainly of collagen and hyaluronic acid, which are natural biopolymer materials contained in human tissues, was used in clinical diabetic wound treatment as a low-cost and easily available wound dressing.

TL;DR: The central role that chemokines play in host defense is illustrated, best demonstrated by the tremendous number of chemokine and Chemokine receptor homologs found in microbial genomes, which deflect the immune response of the host.

TL;DR: Oxidative damage and antioxidative capacity in OA cartilage were investigated in donor-matched pairs of intact and degenerated regions of tissue isolated from the same cartilage explants, suggesting that oxidative stress induces chondrocyte telomere instability and catabolic changes in cartilage matrix structure and composition.

TL;DR: There is no data that any of the IA injections will cause osteophytes to regress or cartilage and meniscus to regenerate in patients with substantial and irreversible bone and cartilage damage, so IA corticosteroid injections are safe and have positive effects for patient satisfaction.

TL;DR: A method is described that leverages the advantages of bottom-up and top-down strategies to incorporate proteins derived from the leukocyte plasma membrane into lipid nanoparticles that retained the versatility and physicochemical properties typical of liposomal formulations and enabled the selective and effective delivery of dexamethasone to inflamed tissues.