Immunohistochemical and electron microscopic study of interaction of Yersinia enterocolitica serotype O8 with intestinal mucosa during experimental enteritis.
C Hanski,U Kutschka,H P Schmoranzer,M Naumann,Andreas Stallmach,Helmut Hahn,H. Menge,Ernst-Otto Riecken +7 more
TL;DR: The integrity of the basement membrane is likely to play a role in determining the route of entry and limit of spread of Y. enterocolitica infection.
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Abstract: The experimental infection of mice with Yersinia enterocolitica serotype O8 was investigated in a quantitative and histological study. The course of bacterial penetration and spreading was precisely determined by immunohistochemical staining. After oral administration, the bacteria passed the epithelial barrier of the ileum and spread into the lamina propria. By preference they entered Peyer's patches, which were about 1,000 times more heavily colonized than the surrounding epithelium of a comparable surface area. The bacteria proliferated in the follicles, from which they spread into the lamina propria of the villi. At either site most of the bacteria multiplied extracellularly, with only a small percentage observed to be present within the phagocytes. The bacteria did not appear to be able to pass the intact basement membrane; hence, the integrity of the basement membrane is likely to play a role in determining the route of entry and limit of spread of Y. enterocolitica infection.
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Citations
Immunological and Electronmicroscopic Studies in Pigs Infected with Yersinia enterocolitica 0:3
TL;DR: The results have shown that inspite of the activation of T and B cell immune response, this infectious agent persisted in the porcine organism.
9
Effect of acute Yersinia enterocolitica infection on intestinal barrier function in the mouse
TL;DR: The data show that epithelial barrier dysfunction plays a role in Y. enterocolitica infection, while Na(+)-glucose cotransport and electrogenic Cl- secretion are unaltered.
9
•Dissertation
An investigation into the interaction of Aeromonas salmonicida and the gastrointestinal tract of rainbow trout and the implications for oral delivery of a live auxotrophic mutant
Steven Michael Jones
- 01 Jan 1996
TL;DR: Investigation into the response of rainbow trout to a live oral vaccine found evidence that cellular immunity is preferentially stimulated by live vaccines and any future work should involve an investigation of the systemic and mucosal cellular response.
8
The Amino-Terminal Part of the Needle-Tip Translocator LcrV of Yersinia pseudotuberculosis Is Required for Early Targeting of YopH and In vivo Virulence.
Sofie Ekestubbe,Jeanette E. Bröms,Tomas Edgren,Maria Fällman,Matthew S. Francis,Åke Forsberg +5 more
TL;DR: This study uses Yersinia as a model and identifies N-terminal lcrV mutants that, similar to the wild-type protein, efficiently promoted expression, secretion and intracellular levels of Yop effectors, yet they were impaired in their ability to inhibit phagocytosis by J774 cells.
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The influence of the cytotoxic necrotizing factor toxin of Yersinia pseudotuberculosis on pathogenesis
Heine, Wiebke, Alexandra
- 06 Jul 2017
TL;DR: Evidence is provided that CNFY is a crucial regulator of Y. pseudotuberculosis pathogenesis, as it modulates inflammation and immune responses by enhancing the translocation of Yersinia effector proteins into host cells and increased early bacterial dissemination to systemic tissues, which was dependent on the inflammasome and IL-1 cytokines.
8
References
Characterization of plasmids and plasmid-associated determinants of Yersinia enterocolitica pathogenesis.
TL;DR: Yersinia enterocolitica isolates harboring a particular species of plasmid deoxyribonucleic acid showed a high degree of lethality for gerbils and caused the detachment of HEp-2 tissue cell monolayers, but invasiveness of HEP-2 cells was shown not to be a plasmids-mediated property.
624
Yersinia enterocolitica, a Primary Model for Bacterial Invasiveness
TL;DR: Yersinia enterocolitica is now the species of Yersinia most frequently isolated from human and animal infections, and among the human pathogens, those isolated in America are more virulent than those isolated elsewhere, especially in Europe and Japan, and these isolates differ biochemically and serologically.
333
7-S collagen: characterization of an unusual basement membrane structure.
TL;DR: The data indicate that 7-S collagen is a unique component of basement membranes which shows a more compact and stable structure than other collageneous proteins.
312
Pathogenecity of Yersinia enterocolitica for mice.
TL;DR: A laboratory infection of Yersinia enterocolitica in mice which closely resembles the naturally acquired human infection is described and a serological response, in the form of agglutinating antibody, begins to appear 2 weeks after infection.
221
Intestinal colonization and virulence of Salmonella in mice.
TL;DR: It is suggested that adhesiveness is neither essential nor sufficient for the virulence of Salmonella and that the usual development of a systemic infection after colonization of the small intestinal Peyer's patches may be subverted by the presence of O-antibody.
175