Immunochemical studies on cholecystokinin. II. Distribution and molecular heterogeneity in the central nervous system and small intestine of man and hog.
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TL;DR: Using sequence-specific radioimmunoassays, the distribution and heterogeneity of cholecystokinin (CCK) has been determined in extracts of tissues from the central nervous system and small intestine of adult man and hog.
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About: This article is published in Journal of Biological Chemistry. The article was published on 10 Jun 1978. and is currently open access. The article focuses on the topics: Cholecystokinin & CCK-4.
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Citations
Distribution of peptide- and catecholamine-containing neurons in the gastro-intestinal tract of rat and guinea-pig: immunohistochemical studies with antisera to substance P, vasoactive intestinal polypeptide, enkephalins, somatostatin, gastrin/cholecystokinin, neurotensin and dopamine beta-hydroxylase.
Marianne Schultzberg,T. Hökfelt,Göran Nilsson,Lars Terenius,Jens F. Rehfeld,M. Brown,Robert Elde,Menek Goldstein,Said S +8 more
TL;DR: The possible coexistence of two peptides in one neuron was studied and evidence was obtained for the occurrence of a somatostatin-like and a gastrin/ CCK-like peptide in the same neurons, which may indicate a common precursor for the two peptided in these particular neurons.
906
Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction.
TL;DR: CCK can be bioassayed in fasting and postprandial human plasma and the studies suggest that CCK may be an important regulator of gallbladder contraction.
Different populations of GABAergic neurons in the visual cortex and hippocampus of cat contain somatostatin- or cholecystokinin- immunoreactive material
TL;DR: The presence of CCK- and somatostatin-immunoreactive material in GABAergic cortical neurons raises the possibility that neuroactive peptides affect GABAergic neurotransmission.
741
Biological actions of cholecystokinin
TL;DR: New findings are presented on potent, nonpeptide CCK antagonists, selective for the two CCK receptor subtypes, which demonstrate that endogenous CCK has biologically important effects on physiology and behavior.
725
Evidence for coexistence of dopamine and CCK in meso-limbic neurones.
TL;DR: Evidence has been obtained that mesencephalic dopamine neurones in the human brain contain similar peptides and the occurrence of peptides in meso-limbic dopamine neurons in the rat brain is described.
716
References
Distribution and concentration of TRH in the rat brain.
TL;DR: Qualitative and quantitative criteria indicate that TRH is present in methanolic extracts prepared from all regions of the rat brain and the greatest concentration of TRH, determined by radioirnmunoassay, was found in the hypothalamus, followed by the posterior pituitary gland, thalamus, brain stem, cerebrum, anterior pituitaries gland, and cerebellum.
292
Evidence for a common evolutionary origin of gastrin and cholecystokinin
LI Larsson,Jens F. Rehfeld +1 more
TL;DR: Evidence is presented that in amphibians and teleosts gastrin and CCK are no longer recognisable as separate hormones, suggesting they have evolved from a common ancestral molecule.
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