Immunochemical approach to characterize advanced glycation end products of the Maillard reaction. Evidence for the presence of a common structure.

TL;DR: The results show that Lys-2 and Lys-163 play almost equal roles in cross-linking of γB-crystallin, and for the first time that significant cross- linking occurs between lysines and non-lysine sites.

TL;DR: The aim of this study is to verify whether AGE levels may promote endothelial cell alterations responsible for vein graft failure.

TL;DR: Data pertaining to dietary AGEs’ involvement in the mechanistic pathogenesis of polycystic ovary syndrome, ovarian dysfunction, as well as the AGES’ effect perinatally on the female offspring reproduction are presented.

TL;DR: In order to detect the localization of AGE in human renal tissues, immunohistochemical staining using the monoclonal anti‐AGE antibody in the glomeruli of 11 patients with DN and 11 age‐matched patients with diffuse mesangial proliferative glomerulonephritis without IgA deposition as controls are performed.

TL;DR: A new method of conjugating horseradish peroxidase with proteins was developed by oxidizing the carbohydrate moiety with sodium periodate and bound to free amino groups of proteins unidirectionally at high efficiencies.

TL;DR: The hemagglutination assays are based on the ability of an antibody to agglutinate red cells, carrying the specific antigen, and have all the advantages in terms of extreme simplicity, speed, and direct visual reading of the results.

TL;DR: Three mutually supportive lines of evidence for oxidation of LDL in vivo are presented and autoantibodies against malondialdehyde-LDL (titers from 512 to greater than 4096) can be demonstrated in rabbit and human sera.

TL;DR: The unexpected discovery of pentose-mediated protein cross-linking raises new questions concerning the aging process and suggests ribose or ribonucleotide metabolites as precursors.