Immunochemical approach to characterize advanced glycation end products of the Maillard reaction. Evidence for the presence of a common structure.
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TL;DR: The results strongly suggest the presence of a common structure in AGE preparations, regardless of whether AGE products are generated from proteins, amino acids, or monoaminocarboxylic acids.
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About: This article is published in Journal of Biological Chemistry. The article was published on 25 Apr 1991. and is currently open access. The article focuses on the topics: Amadori rearrangement & Maillard reaction.
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Citations
In vivo and in vitro evidence for the glycoxidation of low density lipoprotein in human atherosclerotic plaques.
Yoshinobu Imanaga,Noriyuki Sakata,Shigeo Takebayashi,Akira Matsunaga,Jun Sasaki,Kikuo Arakawa,Ryoji Nagai,Seikoh Horiuchi,Hiroyuki Itabe,Tatsuya Takano +9 more
TL;DR: The in vitro results suggest that the glycoxidative modification of LDL may occur in the arterial intima, and may contribute to the development of human atherosclerotic lesions.
73
Immunocytochemical detection of advanced glycated end products in rat renal tissue as a function of age and diabetes
TL;DR: The presence of AGE products in the renal extracellular matrix of old normoglycemic animals and their rapid appearance in hyperglycemia, indicate that AGE Products may participate in the pathogenesis of renal complications.
72
Receptors for proteins modified by advanced glycation endproducts (AGE)—their functional role in atherosclerosis
TL;DR: In vivo and in vitro experiments suggest that AGE-proteins formed extracellularly in atherosclerotic lesions are endocytosed by macrophages through MSR-A in the early stage, and by SMCs through the novel AGE -receptor in the advanced stage, implicating functional contribution of the A GE-receptor-mediated interaction with these cells to atherosclerosis processes in arterial walls.
71
Accelerated formation of N epsilon-(carboxymethyl) lysine, an advanced glycation end product, by glyoxal and 3-deoxyglucosone in cultured rat sensory neurons.
Hisayoshi Niwa,Akinori Takeda,Masakazu Wakai,Toshio Miyata,Yoshinari Yasuda,Terunori Mitsuma,Kiyoshi Kurokawa,Gen Sobue +7 more
TL;DR: Glyoxal and 3-deoxyglucosone (3-DG), AGE precursors, induced N epsilon-(carboxymethyl) lysine (CML), a well characterized and major AGE structure, in cultured rat sensory neurons in a time- and dose-dependent manner in the first evidence for the induction of AGEs in cultured neuronal cells.
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