Immunity and Inflammation in Atherosclerosis.
Dennis Wolf,Klaus Ley,Klaus Ley +2 more
980
TL;DR: The pathogenesis of atherosclerosis is discussed with a focus on adaptive immunity and some limitations of animal models and the need for models that are tailored to better translate to human Atherosclerosis and ultimately progress in prevention and treatment are discussed.
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Abstract: There is now overwhelming experimental and clinical evidence that atherosclerosis is a chronic inflammatory disease. Lessons from genome-wide association studies, advanced in vivo imaging techniques, transgenic lineage tracing mice, and clinical interventional studies have shown that both innate and adaptive immune mechanisms can accelerate or curb atherosclerosis. Here, we summarize and discuss the pathogenesis of atherosclerosis with a focus on adaptive immunity. We discuss some limitations of animal models and the need for models that are tailored to better translate to human atherosclerosis and ultimately progress in prevention and treatment.
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Citations
Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel
Jan Borén,M. John Chapman,M. John Chapman,Ronald M. Krauss,Chris J. Packard,Jacob F. Bentzon,Jacob F. Bentzon,Christoph J. Binder,Mat J.A.P. Daemen,Linda L. Demer,Robert A. Hegele,Stephen J. Nicholls,Børge G. Nordestgaard,Gerald F. Watts,Gerald F. Watts,Eric Bruckert,Sergio Fazio,Brian A. Ference,Brian A. Ference,Ian D. Graham,Jay D. Horton,Ulf Landmesser,Ulrich Laufs,Luis Masana,Gerard Pasterkamp,Frederick J. Raal,Kausik K. Ray,Heribert Schunkert,Marja-Riitta Taskinen,Bart van de Sluis,Olov Wiklund,Lale Tokgozoglu,Alberico L. Catapano,Henry N. Ginsberg +33 more
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References
Immunotherapy With Tolerogenic Apolipoprotein B-100–Loaded Dendritic Cells Attenuates Atherosclerosis in Hypercholesterolemic Mice
Andreas Hermansson,Daniel K. Johansson,Daniel F. J. Ketelhuth,John Andersson,Xinghua Zhou,Göran K. Hansson +5 more
TL;DR: Tolerogenic DCs pulsed with ApoB100 reduced the autoimmune response against low-density lipoprotein and may represent a novel possibility for treatment or prevention of atherosclerosis.
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