Immunity and Inflammation in Atherosclerosis.
Dennis Wolf,Klaus Ley,Klaus Ley +2 more
980
TL;DR: The pathogenesis of atherosclerosis is discussed with a focus on adaptive immunity and some limitations of animal models and the need for models that are tailored to better translate to human Atherosclerosis and ultimately progress in prevention and treatment are discussed.
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Abstract: There is now overwhelming experimental and clinical evidence that atherosclerosis is a chronic inflammatory disease. Lessons from genome-wide association studies, advanced in vivo imaging techniques, transgenic lineage tracing mice, and clinical interventional studies have shown that both innate and adaptive immune mechanisms can accelerate or curb atherosclerosis. Here, we summarize and discuss the pathogenesis of atherosclerosis with a focus on adaptive immunity. We discuss some limitations of animal models and the need for models that are tailored to better translate to human atherosclerosis and ultimately progress in prevention and treatment.
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References
Conventional B2 B Cell Depletion Ameliorates whereas Its Adoptive Transfer Aggravates Atherosclerosis
Tin Kyaw,Christopher Tay,Abdul Waheed Khan,Vanessa Dumouchel,Anh Cao,Kelly To,Merilyn Kehry,Robert Dunn,Alex Agrotis,Peter G. Tipping,Alex Bobik,Ban-Hock Toh +11 more
TL;DR: It is found that selective B cell depletion in apolipoprotein E-deficient mice using a well-characterized mAb to mouse CD20 reduced atherosclerosis development and progression without affecting the hyperlipidemia imposed by a high-fat diet.
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B Cells and Humoral Immunity in Atherosclerosis
TL;DR: A review of recent insights on the role of B cells and various immunoglobulin classes and how these may mediate their effects in atherosclerotic lesion formation is focused on.
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Inhibition of Atherosclerosis in ApoE-Null Mice by Immunization with ApoB-100 Peptide Sequences
Gunilla Nordin Fredrikson,Ingrid Söderberg,Marie W. Lindholm,Paul C. Dimayuga,Kuang-Yuh Chyu,Prediman K. Shah,Jan Nilsson +6 more
TL;DR: It is reported here that immunization with apoB-100 peptide sequences, against which high levels of IgG and IgM antibodies are present in healthy human controls, reduce atherosclerosis in apoE-null mice by about 60%.
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Influence of Interferon-γ on the Extent and Phenotype of Diet-Induced Atherosclerosis in the LDLR-Deficient Mouse
Chiara Buono,Carolyn E. Come,George Stavrakis,Graham F. Maguire,Philip W. Connelly,Andrew H. Lichtman +5 more
TL;DR: Direct evidence is provided that IFN-&ggr; influences atherosclerosis development and phenotype in the LDLR-deficient mouse, independent of changes in blood lipoprotein profiles.
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T Cells in Atherogenesis. For Better or For Worse
TL;DR: This review summarizes knowledge of T cells in atherogenesis, their potential antigens, their contact-dependent activities, and their secretion of inflammatory and antiinflammatory mediators, aiming to illustrate how T cells can aggravate or attenuate this disease through cross-talk with other cells within or outside the atherosclerotic plaque.
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