Journal Article10.1016/S0006-3223(03)00412-8
Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma
Guillaume Vaiva,François Ducrocq,Karine Jezequel,Benoit Averland,Philippe Lestavel,Alain Brunet,Charles R. Marmar +6 more
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TL;DR: It is suggested that propranolol may be useful for mitigating PTSD symptoms or perhaps even preventing the development of PTSD.
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About: This article is published in Biological Psychiatry. The article was published on 01 Nov 2003. The article focuses on the topics: Anxiety disorder.
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Citations
Postreactivation glucocorticoids impair recall of established fear memory.
TL;DR: Findings provide a rodent model for a potential treatment of established acquired anxiety disorders in humans, as suggested by others, based on a mechanism of enhanced extinction, that glucocorticoids not only decrease fear memory retrieval but, in addition, augment consolidation of fear memory extinction rather than decreasing reconsolidation.
262
Conceptually driven pharmacologic approaches to acute trauma.
TL;DR: Primary prevention of posttraumatic stress disorder (PTSD) entails intervening in the aftermath of a traumatic event to forestall the development of PTSD.
261
Emerging treatments for PTSD
TL;DR: This paper reviews emerging psychotherapeutic and pharmacologic interventions for the treatment of PTSD and describes recent findings regarding novel pharmacologic approaches including propranolol, ketamine, prazosin, and methylenedioxymethamphetamine.
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Noradrenergic signaling in the amygdala contributes to the reconsolidation of fear memory: treatment implications for PTSD.
Jacek Dȩbiec,Joseph E. LeDoux +1 more
TL;DR: Using classical fear conditioning in rats, it is demonstrated that noradrenergic blockade in the LA following reactivation of fear memory by retrieval disrupts memory reconsolidation and lastingly impairs fear memory, suggesting that norads may be useful in attenuating traumatic memories, even well‐consolidated old memories, in PTSD.
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Noradrenergic enhancement of reconsolidation in the amygdala impairs extinction of conditioned fear in rats - A possible mechanism for the persistence of traumatic memories in PTSD
TL;DR: Postretrieval β‐adrenergic stimulation in the amygdala enhances reconsolidation of fear memories, making them resistant to extinction and contributing to persistence and severity of traumatic memories.
235
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The Mini International Neuropsychiatric Interview (MINI). A short diagnostic structured interview: reliability and validity according to the CIDI
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TL;DR: The Mini International Neuropsychiatric Interview (MINI) as mentioned in this paper is a short diagnostic structured interview (DSI) developed in France and the United States to explore 17 disorders according to Diagnostic and Statistical Manual (DSM)-III-R diagnostic criteria.
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The validity of the Mini International Neuropsychiatric Interview (MINI) according to the SCID-P and its reliability
David V. Sheehan,Yves Lecrubier,K. Harnett Sheehan,J. Janavs,E Weiller,A. Keskiner,John A. Schinka,E. Knapp,M. Sheehan,Dunbar Geoffrey Charles +9 more
TL;DR: The results supported the validity and reliability of the MINI and the application of short structured interviews in clinical and research settings is discussed.
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Beta-adrenergic activation and memory for emotional events.
TL;DR: The impairment of propranolol on memory of the emotional story was not due either to reduced emotional responsiveness or to nonspecific sedative or attentional effects, which support the hypothesis that enhanced memory associated with emotional experiences involves activation of the β-adrenergic system.
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Pilot study of secondary prevention of posttraumatic stress disorder with propranolol
Roger K. Pitman,Kathy M. Sanders,Randall M. Zusman,Anna R. Healy,Farah Cheema,Natasha B. Lasko,Natasha B. Lasko,Larry Cahill,Scott P. Orr,Scott P. Orr +9 more
TL;DR: These pilot results suggest that acute, posttrauma propranolol may have a preventive effect on subsequent PTSD.
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