Journal Article10.1016/J.MRI.2004.10.001
Imaging iron stores in the brain using magnetic resonance imaging.
E. Mark Haacke,Norman Y.C. Cheng,Michael J. House,Qiang Liu,Jaladhar Neelavalli,Robert J. Ogg,Adnan Khan,Muhammad Ayaz,Wolff M. Kirsch,Andre Obenaus +9 more
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TL;DR: This review examines the response of the magnetic resonance visible iron in tissue that produces signal changes in both magnitude and phase images that seem to correlate with brain iron content, but still have not been successfully exploited to accurately and precisely quantify brain iron.
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About: This article is published in Magnetic Resonance Imaging. The article was published on 01 Jan 2005. The article focuses on the topics: Quantitative susceptibility mapping & Ferritin.
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The role of iron in brain ageing and neurodegenerative disorders
TL;DR: MRI can often identify changes in iron homoeostasis, thus providing a potential diagnostic biomarker of neurodegenerative diseases and an important avenue to reduce iron accumulation is the use of iron chelators that are able to cross the blood-brain barrier, penetrate cells, and reduce excessive iron accumulation, thereby affording neuroprotection.
Susceptibility-weighted imaging: technical aspects and clinical applications, part 1.
TL;DR: Susceptibility-weighted imaging (SWI) is a new neuroimaging technique, which uses tissue magnetic susceptibility differences to generate a unique contrast, different from that of spin density, T1, T2, and T2*.
Quantitative susceptibility mapping (QSM): Decoding MRI data for a tissue magnetic biomarker.
Yi Wang,Tian-Yu Liu +1 more
TL;DR: This paper attempts to summarize the basic physical concepts and essential algorithmic steps in QSM, to describe clinical and technical issues under active development, and to provide references, codes, and testing data for readers interested inQSM.
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Susceptibility-weighted imaging: technical aspects and clinical applications, part 2.
TL;DR: It is concluded that SWI often offers complementary information valuable in the diagnosis and potential treatment of patients with neurologic disorders, as well as a variety of neurovascular and neurodegenerative disease applications for SWI.
Quantitative imaging of intrinsic magnetic tissue properties using MRI signal phase: an approach to in vivo brain iron metabolism?
TL;DR: The findings suggest that susceptibility contrast, and therewith also phase contrast, are not only linked to the storage iron concentration but are also significantly influenced by other sources such as myelin, and caution should be exercised when drawing conclusions about iron concentrations when directly assessing processed phase information.
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References
Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains.
Peter Riederer,Emin Sofic,Wolf-Dieter Rausch,Bruno Schmidt,Gavin P. Reynolds,Kurt A. Jellinger,Moussa B.H. Youdim +6 more
TL;DR: Reduced glutathione and the shift of the iron (II)/iron (III) ratio in favor of iron ( III) suggest that these changes might contribute to pathophysiological processes underlying PD.
1.4K
Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging.
TL;DR: The T1 relaxivity can be improved (and the T2/T2* effect can be reduced) using small particles and T1-weighted imaging sequences, and superparamagnetic agents open up an important field for research in MR imaging.
Seed Development and Germination
Jaime Kigel,Gad Galili +1 more
- 01 Jan 1995
TL;DR: This chapter discusses the implications of seed-associated mycoflora during storage biochemical processes during osmotic priming of seeds improvement of protein quality in seeds overproduction of essential amino acids in seeds artificial seeds.
1.2K
Theory of NMR signal behavior in magnetically inhomogeneous tissues: the static dephasing regime.
TL;DR: An approach is developed that analytically describes the NMR signal in the static dephasing regime where diffusion phenomena may be ignored and the signal decays exponentially with an argument which depends quadratically on TE.
1.2K
In vivo visualization of gene expression using magnetic resonance imaging
Angelique Y. Louie,Martina M. Hüber,Eric T. Ahrens,Ute Rothbächer,Rex Moats,Rex Moats,Russell E. Jacobs,Scott E. Fraser,Thomas J. Meade +8 more
TL;DR: The results offer the promise of in vivo mapping of gene expression in transgenic animals and validate a general approach for constructing a family of MRI contrast agents that respond to biological activity.
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