Patent
Il-5 transgenic mouse
James J. Lee,Nancy A. Lee +1 more
- 09 Apr 1997
12
TL;DR: In this article, a transgenic mouse is provided, the cells of which contain and express IL-5 in a cell type- or tissue-specific manner and in an amount which results in an IL5-associated pathology.
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Abstract: A transgenic mouse is provided, the cells of which contain and express IL-5 in a cell type- or tissue-specific manner and in an amount which results in an IL-5-associated pathology. Also provided are expression cassettes comprising an IL-5 gene, operably linked to a cell type- or tissue-specific transcriptional control sequence and methods of using transgenic mice comprising the expression cassettes.
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Citations
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TL;DR: In this article, the present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to Interferonα at the amino acid sequence level.
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TL;DR: In this paper, the authors provided DNA sequences whose genes are induced at least by Wnt-1 and their associated vectors and host cells. But they did not provide any methods for producing the polypeptides.
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David J. Steele,John C. Gano +1 more
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TL;DR: In this article, a method of expanding a structure in a well-bore includes the steps of: positioning the structure in an unexpanded configuration in the wellbore, the structure including a wall made up of multiple layers; expanding the structure to an expanded configuration while permitting relative displacement between the layers; and then preventing relative displacement among the layers.
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TL;DR: In this article, the authors proposed a method of inhibiting infection of a cell susceptible to HCV infection which comprises contacting the cell with an amount of a compound effective to inhibit binding of an HCV envelope glycoprotein to a DC-SIGN protein present on the surface of the cell, so as to thereby inhibit infection of the infected cell.
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- 22 Sep 2011
TL;DR: In this paper, transgenic animals that overexpress TL1A in a tissue specific manner were used to model inflammatory bowel disease (IBM) such as colitis, Crohn's disease and ulcerative colitis.
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References
Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.
TL;DR: Results indicate that IL-5 and eosinophils are central mediators in the pathogenesis of allergic lung disease.
Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.
David B. Corry,Hans G. Folkesson,Martha L. Warnock,David J. Erle,Michael A. Matthay,Jeanine P. Wiener-Kronish,Richard M. Locksley +6 more
TL;DR: These data implicate IL-4 generated during the period of lymphocyte priming with antigen in establishing the cascade of responses required to generate airway hyperractivity to inhaled antigen and suggest a role for IL-5 or eosinophils.
Production of pharmaceutical proteins from transgenic animals
TL;DR: Predictive reports suggest that 10% of the recombinant proteins, corresponding to a 100 million dollars annual market, will be prepared from the milk of transgenic animals by the end of the century, and progress to improving the efficiency of this process inclines to be reasonably optimistic.
491
Transgenic livestock: Progress and prospects for the future
TL;DR: Before transgenic farm animals become a common component of the livestock production industry, a number of formidable hurdles must be overcome.
427
CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea.
Hiroshi Nakajima,Itsuo Iwamoto,Sanae Tomoe,Ryutaro Matsumura,Hisao Tomioka,Kiyoshi Takatsu,Sho Yoshida +6 more
TL;DR: Results provide direct evidence that CD4+ but not CD8+ T-cells mediate antigen-induced eosinophil recruitment in the airways and that IL-5 mediates this eos inophil recruited in the trachea.
373
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