IL-32 promoter SNP rs4786370 predisposes to modified lipoprotein profiles in patients with rheumatoid arthritis.
Michelle S M A Damen,Rabia Agca,Suzanne Holewijn,Jacqueline de Graaf,Jéssica Cristina dos Santos,Piet L. C. M. van Riel,Jaap Fransen,Marieke J H Coenen,Michael T. Nurmohamed,Mihai G. Netea,Charles A. Dinarello,Leo A. B. Joosten,Bas Heinhuis,Calin D. Popa +13 more
23
TL;DR: A functional effect of a promoter single-nucleotide polymorphism (SNP) in IL32 is shown on lipid profiles in RA patients and individuals, suggesting a possible protective role of this SNP against CVD.
read more
Abstract: Patients with rheumatoid arthritis (RA) are at higher risk of developing cardiovascular diseases (CVD). Interleukin (IL)-32 has previously been shown to be involved in the pathogenesis of RA and might be linked to the development of atherosclerosis. However, the exact mechanism linking IL-32 to CVD still needs to be elucidated. The influence of a functional genetic variant of IL-32 on lipid profiles and CVD risk was therefore studied in whole blood from individuals from the NBS cohort and RA patients from 2 independent cohorts. Lipid profiles were matched to the specific IL-32 genotypes. Allelic distribution was similar in all three groups. Interestingly, significantly higher levels of high density lipoprotein cholesterol (HDLc) were observed in individuals from the NBS cohort and RA patients from the Nijmegen cohort homozygous for the C allele (p = 0.0141 and p = 0.0314 respectively). In contrast, the CC-genotype was associated with elevated low density lipoprotein cholesterol (LDLc) and total cholesterol (TC) in individuals at higher risk for CVD (plaque positive) (p = 0.0396; p = 0.0363 respectively). Our study shows a functional effect of a promoter single-nucleotide polymorphism (SNP) in IL32 on lipid profiles in RA patients and individuals, suggesting a possible protective role of this SNP against CVD.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Interleukin-32 in chronic inflammatory conditions is associated with a higher risk of cardiovascular diseases.
TL;DR: It is argued for a role of IL-32 in the increased prevalence of CVD in patients with chronic inflammatory disorders and the substantial contribution of the inflammatory status of the patients to the development and stability of atherosclerotic plaques.
55
Molecular interactions and functions of IL-32
TL;DR: Current literature on molecular interactions of IL‐32 with other proteins are discussed and the role of intracellular IL-32 as a metabolic regulator and its role in antimicrobial host defense is reviewed.
53
The role of pro-inflammatory cytokines in lipid metabolism of metabolic diseases.
Yan Chen,Chunyan Yu,Weimin Deng +2 more
TL;DR: An overview of the progress that has been made in the roles of different pro-inflammatory cytokines in lipid metabolism of metabolic diseases including cancer is provided.
51
Clinical Implications of IL-32, IL-34 and IL-37 in Atherosclerosis: Speculative Role in Cardiovascular Manifestations of COVID-19
TL;DR: In this paper, the role of cytokines in atherosclerosis was investigated and it was speculated that these cytokines may contribute to the increased occurrence of atherosclerotic plaque rupture seen in patients with COVID-19 infection.
Prognostic significance of high-mobility group box protein 1 genetic polymorphisms in rheumatoid arthritis disease outcome.
Li-Hong Wang,Min-Huan Wu,Po-Chun Chen,Chen-Ming Su,Guo-Hong Xu,Chien-Chung Huang,Chun-Hao Tsai,Yuan-Li Huang,Chih-Hsin Tang,Chih-Hsin Tang +9 more
TL;DR: Rheumatoid arthritis (RA) is a systemic inflammatory disease that causes chronic inflammation of the joints that offers promise for guiding treatment and improving outcomes in RA, and the risk factors associated with HMGB1 SNPs in the development of RA disease in the Chinese Han population are examined.
References
A simple salting out procedure for extracting DNA from human nucleated cells
TL;DR: A rapid, safe and inexpensive method was developed to simplify the deprotein-ization procedure that yielded quantities comparable to those obtained from phenol-chloroform extractions, rendering the entire process of RFLP analysis free of toxic materials.
21.6K
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
21.2K
High density lipoprotein as a protective factor against coronary heart disease: The Framingham study
TL;DR: The major potent lipid risk factor was HDL cholesterol, which had an inverse association with the incidence of coronary heart disease in either men or women and these associations were equally significant even when other lipids and other standard risk factors for coronaryHeart disease were taken into consideration.
5.3K
Progress and challenges in translating the biology of atherosclerosis
TL;DR: Understanding how to combine experimental and clinical science will provide further insight into atherosclerosis and could lead to new clinical applications.
3.8K