Journal Article10.1016/0016-5085(89)90384-3
Identification of neurotransmitters regulating intestinal peristaltic reflex in humans.
TL;DR: The components of the intestinal peristaltic reflex in humans were examined and the neurotransmitters responsible for them identified for the first time i isolated flat sheet segments of intestine, supporting the participation of vasoactive intestinal peptide motor neurons in descending relaxation and tachykinin motor neurons as well as cholinergicMotor neurons in ascending contraction.
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About: This article is published in Gastroenterology. The article was published on 01 Dec 1989. The article focuses on the topics: Reflex.
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Citations
The morphology and projections of retrogradely labeled myenteric neurons in the human intestine.
TL;DR: Myenteric neurons labeled from each target had characteristic size, morphology, polarity, and length of projections, indicating that there is a high degree of organization in the human enteric nervous system.
Characterization of the [125I]-neurokinin A binding site in the circular muscle of human colon.
TL;DR: Binding of the radioligand [125I]‐NKA to membranes from circular muscle is predominantly to the NK2 receptor, whereas curves to NKA and NKB were unaffected.
Expression of mRNA for vasoactive intestinal peptide in normal human colon and during inflammation.
A. Schulte-Bockholt,John G. Fink,D.A. Meier,Mary F. Otterson,Gordon L. Telford,K. Hopp,Timothy R. Koch +6 more
TL;DR: The observations suggest that decreased vasoactive intestinal peptide gene expression or abnormal post-transcriptional processing are not primary defects in this disorder of chronic inflammation, and support the alternative hypothesis that axonal degeneration in ulcerative colitis could result in increased expression of neuronal vaso active intestinal peptides mRNA.
Microsomal Prostaglandin E Synthase-1 Plays a Critical Role in Long-term Motility Dysfunction after Bowel Obstruction.
You Min Lin,Yu Fu,Shrilakshmi Hegde,Yanbo Tang,Yanbo Tang,Ravi S. Radhakrishnan,Xuan Zheng Shi +6 more
TL;DR: In this article, partial colon obstruction was induced in rats with an obstruction band, which was released 7 days later, and they were further studied in the post-BO state, showing that motility dysfunction is present not only during bowel obstruction (BO), but after obstruction is resolved.
Developmental and age-dependent plasticity of GABAA receptors in the mouse colon: Implications in colonic motility and inflammation
TL;DR: The data provide the first demonstration of the molecular and functional plasticity of the GI GABAAR system over the course of a lifetime, and its possible role in mediating the age-induced colonic inflammation associated with healthy ageing.
References
Vasoactive intestinal peptide: A neurotransmitter for relaxation of the rabbit internal anal sphincter
TL;DR: The circular smooth muscle of the rabbit internal anal sphincter, tested in vitro, exhibited spontaneous resting tonus and relaxed with neural stimuli of 0.05-0.5-ms duration and 1-10-Hz frequency, consistent with VIP being an inhibitory neurotransmitter responsible for relaxation of the internal analSpin.
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Relaxant Neurotransmitter in Tenia Coli of the Guinea Pig
J. R. Grider,M. B. Cable,K.N. Bitar,G. M. Makhlouf +3 more
- 01 Jan 1985
TL;DR: The results favor VIP (and probably peptide histidine isoleucine, a relaxant homologue known to be cosynthesized with VIP) as the main neural mediator of relaxation in tenia coli.
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Role of vasoactive intestinal polypeptide in the internal anal sphincter relaxation of the opossum.
Samuel Nurko,Satish Rattan +1 more
TL;DR: It is concluded that VIP acts as an inhibitory neurotransmitter for IAS relaxation during the rectoanal reflex.
Vasoactive intestinal polypeptide mediates cholecystokinin-induced relaxation of the sphincter of Oddi.
TL;DR: It is demonstrated that CCK-8 relaxes the canine sphincter of Oddi via a noncholinergic, nonadrenergic neural pathway involving VIP and the intracellular mechanism mediating CCK/VIP relaxation involves generation of cAMP.
Comparison of the effect of vasoactive intestinal polypeptide and non-adrenergic non-cholinergic neurone stimulation in the cat gastric fundus.
TL;DR: The results are compatible with the hypothesis that VIP is involved in the NANC relaxation of the cat gastric fundus, although participation of a non-VIP component cannot be excluded.
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