Identification and Characterization of a Novel Androgen Receptor Coregulator ARA267-α in Prostate Cancer Cells *
Xin Wang,Shuyuan Yeh,Guan Wu,Cheng Lung Hsu,Liang Wang,Tzuying Chiang,Yue Yang,Yinglu Guo,Chawnshang Chang +8 more
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TL;DR: The isolation of a new AR coregulator with a calculated molecular mass of 267 kDa named the androgen receptor-associated protein 267-α (ARA267-α) is reported, containing the SET domain with an exceptionally large molecular mass that can enhance AR transactivation in prostate cancer cells.
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About: This article is published in Journal of Biological Chemistry. The article was published on 02 Nov 2001. and is currently open access. The article focuses on the topics: Androgen Response Element & Androgen receptor.
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Citations
Androgen Receptor (AR) Coregulators: An Overview
TL;DR: AR demonstrates distinct differences in its interaction with coregulators from other steroid receptors due to differences in the functional interaction between AR domains, possibly resulting in alterations in the dynamic interactions between coregulator complexes.
Understanding the language of Lys36 methylation at histone H3
TL;DR: Although H3K36 methylation is most commonly associated with the transcription of active euchromatin, it has also been implicated in diverse processes, including alternative splicing, dosage compensation and transcriptional repression, as well as DNA repair and recombination.
Androgen Receptor (AR) Coregulators: A Diversity of Functions Converging on and Regulating the AR Transcriptional Complex
TL;DR: The current review aims to provide an overview of the AR coregulator proteins identified to date and to propose a classification of these AR coreGulator proteins according to the function(s) ascribed to them, to increase the understanding of the cellular pathways that converge on the AR to ensure an appropriate transcriptional response to androgens.
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Unsafe SETs: histone lysine methyltransferases and cancer
TL;DR: The evidence for a connection between SET-domain-containing proteins and cancer is surveyed and it is proposed that deregulation of SET- domain function has an important role in carcinogenesis.
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The Target of the NSD Family of Histone Lysine Methyltransferases Depends on the Nature of the Substrate
Yan Li,Patrick Trojer,Chong-Feng Xu,Peggie Cheung,Alex J. Kuo,William J. Drury,Qi Qiao,Thomas A. Neubert,Rui-Ming Xu,Rui-Ming Xu,Or Gozani,Danny Reinberg +11 more
TL;DR: It is demonstrated that NSD2 can exhibit disparate target preferences based on the nature of the substrate provided, and proposed that DNA acts as an allosteric effector of N SD2 such that H3K36 becomes the preferred target.
297
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•Journal Article
Polymorphic CAG and GGN repeat lengths in the androgen receptor gene and prostate cancer risk: a population-based case-control study in China.
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