Open Access
Hypoxic locomotor rehabilitation for incomplete spinal cord injury
Ela B. Plow,Michael G. Fehlings +1 more
- 01 Jan 2014
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TL;DR: Capitalizing on the potential for plasticity and employing methods that can augment this potential are the 2 driving themes in current rehabilitation research, and Hayes et al.2 present a study that sought to address both.
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Abstract: Neurorehabilitation is experiencing a paradigm shift toward treatments that are both effective and efficient, driven by increasing demands upon clinical practice and the staggering burden of health care expenditures. The impetus is toward finding ways to maximize the potential for recovery by targeting networks spared by the lesion. Residual networks can undergo reorganization with recovery, involving plasticity or improved efficiency at the level of preexisting synapses and sprouting from surviving fibers for creation of new circuits.1 Capitalizing on the potential for plasticity and employing methods that can augment this potential are the 2 driving themes in current rehabilitation research. In this issue of Neurology®, Hayes et al.2 present a study that sought to address both.
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Citations
Expression of Neuron Specific Neuronal Nuclei Protein (NeuNNP) by AAV2 Shows Diagnosis Ability in Spinal Cord Injury Using Neural Stem Cells
Prithiv Kumar Kr,Albert Alukkal +1 more
- 01 Jan 2021
TL;DR: The improved scores on inclined plane test of BBB (Basso-BettieBresnahan) scale and footprint analysis of functional recovery when compared with vehicle control of AAV2 treatment showed inclination in NeuNNP, neuromodelin GAP43 and neurofilament NF200 and declination in Glial Fibrillary Acidic Protein (GFAP).
Can Controlled Hypoxia Be Beneficial After Spinal Cord Injury
TL;DR: Animal studies have suggested that intermittent, repeated episodes of hypoxia after spinal cord injury may upregulate release of intrinsic neurotropic neurotransmitter levels.
References
Plasticity of motor systems after incomplete spinal cord injury
TL;DR: Functional and anatomical evidence exists that spontaneous plasticity can be potentiated by activity, as well as by specific experimental manipulations, which prepare the way to a better understanding of rehabilitation treatments and to the development of new approaches to treat spinal cord injury.
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BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia
Tracy L. Baker-Herman,David D. Fuller,Ryan W. Bavis,A. G. Zabka,Francis J. Golder,Nicholas J. Doperalski,Rebecca A. Johnson,Jyoti J. Watters,Gordon S. Mitchell +8 more
TL;DR: It is found that intermittent hypoxia elicited serotonin-dependent increases in BDNF synthesis in ventral spinal segments containing the phrenic nucleus, and the magnitude of these BDNF increases correlated with pLTF magnitude.
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Daily intermittent hypoxia enhances walking after chronic spinal cord injury: a randomized trial.
Heather Hayes,Arun Jayaraman,Megan Herrmann,Gordon S. Mitchell,William Z. Rymer,Randy D. Trumbower +5 more
TL;DR: In this paper, the authors showed that daily acute intermittent hypoxia (dAIH) and dAIH combined with overground walking improved walking speed and endurance in persons with chronic incomplete spinal cord injury (iSCI).
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Assessment of Impairment in Patients with Acute Traumatic Spinal Cord Injury: A Systematic Review of the Literature
TL;DR: The ASIA Standards represent an appropriate instrument to categorize and evaluate spinal cord injured adults over time with respect to their motor and sensory function and further investigation of the psychometric properties is recommended due to a lack of studies focused on some key elements of responsiveness.
An engineered transcription factor which activates VEGF-A enhances recovery after spinal cord injury.
Yang Liu,Sarah A. Figley,Sarah A. Figley,S. Kaye Spratt,Gary Lee,Dale Ando,Richard T. Surosky,Michael G. Fehlings,Michael G. Fehlings +8 more
TL;DR: The data suggest that activation of VEGF-A via the administration of an engineered ZFP transcription factor holds promise as a therapy for SCI and potentially other forms of neurotrauma.
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