Book Chapter10.1016/B978-0-444-87137-4.50037-0
Hypothesis Combination and Context Sensitive Classification for Chromosome Aberration Scoring
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TL;DR: Part of a system for chromosome aberration scoring by detecting dicentric chromosomes is described, which aims to combine multiple knowledge sources and to use model-determined constraints in an adaptive classifier to provide a high performance level.
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Abstract: This paper describes part of a system for chromosome aberration scoring by detecting dicentric chromosomes. Although it has been programmed in a traditional procedural computing style, it aims to combine multiple knowledge sources and to use model-determined constraints in an adaptive classifier to provide a high performance level. Chromosome centromere candidates are independendy hypothesised by structural analysis of the chromosome boundary and by analysis of the density distribution along the chromosome axis. For each candidate of either type, a common feature set which is based on a third, independent structural analysis, is measured in order to test the hypotheses. A classifier for centromere candidates is constructed from the set of candidates within a cell itself, by constraining feature space using strong model assumptions. The relationship of the analysis components described to a proposed complete system is outlined.
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Citations
Statistical methods in diagnosis
TL;DR: Motivations are presented for exploring formal statistical methods for use in medical diagnosis and methods for assessing diagnostic performance are outlined.
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An Automated Chromosome Aberration Scoring System
Th. Lörch,C. Wittler,G. Stephan,J. Bille +3 more
- 01 Jan 1989
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Biological Dosimetry After Radiation Accidents
D. C. Lloyd,A. A. Edwards +1 more
- 01 Jan 1990
TL;DR: The frequency of chromosomal aberrations observed in cultured peripheral blood lymphocytes has been used as a biological dosemeter for assessing accidental overexposures to ionizing radiation and has been developed into a routine procedure in radiological protection.
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A system for fluorescence metaphase finding and scoring of chromosomal translocations visualized by in situ hybridization.
TL;DR: The development of a system to detect metaphases on the basis of a fluorescent counterstain and subsequently analyze the number of translocations with the aid of whole chromosome paints fluorescing in a different colour is described.
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References
Radiation-induced chromosome aberrations in nuclear-dockyard workers.
TL;DR: There was a significant increase in chromosome damage with increasing exposure, aberration frequency was a linear function of dose and was influenced by age and time of blood sampling after exposure.
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An assessment of the metaphase finding capability of the Cytoscan 110.
TL;DR: With cultures of X-irradiated blood it was shown that the criteria by which the Cytoscan locates metaphases and ranks their appearance do not introduce bias in the yields of dicentric and other unstable chromosome-type aberrations.
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Human chromosome analysis by machine
Jim Piper,Claes Lundsteen +1 more
TL;DR: Computer assisted chromosome analysis is now becoming routine in human cytogenetics laboratories, but the initial hopes of the machine developers have not been realized.
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