Journal Article10.1210/JCEM.78.2.8106608
Hypothalamic-pituitary-adrenal axis dysregulation in sexually abused girls.
M. D. De Bellis,George P. Chrousos,Lorah D. Dorn,L. Burke,K. Helmers,Mitchel A. Kling,Penelope K. Trickett,F. W. Putnam +7 more
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TL;DR: The hypothalamic-pituitary-adrenal axis was characterized of a self-selected sample of sexually abused and control girls recruited from a prospective longitudinal study to characterized the biological manifestations and sequelae of childhood sexual abuse.
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Abstract: Childhood sexual abuse is associated with an increased incidence of age-concurrent and adult psychopathology. Little is known, however, about the biological manifestations and sequelae of childhood sexual abuse. In this study, we characterized the hypothalamic-pituitary-adrenal axis of a self-selected sample of sexually abused and control girls recruited from a prospective longitudinal study. Plasma ACTH and total and free cortisol responses to ovine CRH (oCRH) stimulation were measured in 13 sexually abused and 13 control girls, aged 7-15 yr. Psychiatric profiles and 24-h urinary free cortisol (UFC) measures were also obtained. Sexually abused girls had a greater incidence of suicidal ideation (chi 2 = 4.51; df = 1; P < 0.05), suicide attempts (chi 2 = 4.51; df = 1; P < 0.05), and dysthymia (chi 2 = 8.85; df = 1; P < 0.01) than control girls. Sexually abused girls showed significantly lower basal (t = 2.1; df = 24; P < 0.05), and net oCRH stimulated (t = 2.2; df = 24; P < 0.05) ACTH levels and significan...
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