Journal Article10.1210/JCEM.78.2.8106608
Hypothalamic-pituitary-adrenal axis dysregulation in sexually abused girls.
M. D. De Bellis,George P. Chrousos,Lorah D. Dorn,L. Burke,K. Helmers,Mitchel A. Kling,Penelope K. Trickett,F. W. Putnam +7 more
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TL;DR: The hypothalamic-pituitary-adrenal axis was characterized of a self-selected sample of sexually abused and control girls recruited from a prospective longitudinal study to characterized the biological manifestations and sequelae of childhood sexual abuse.
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Abstract: Childhood sexual abuse is associated with an increased incidence of age-concurrent and adult psychopathology. Little is known, however, about the biological manifestations and sequelae of childhood sexual abuse. In this study, we characterized the hypothalamic-pituitary-adrenal axis of a self-selected sample of sexually abused and control girls recruited from a prospective longitudinal study. Plasma ACTH and total and free cortisol responses to ovine CRH (oCRH) stimulation were measured in 13 sexually abused and 13 control girls, aged 7-15 yr. Psychiatric profiles and 24-h urinary free cortisol (UFC) measures were also obtained. Sexually abused girls had a greater incidence of suicidal ideation (chi 2 = 4.51; df = 1; P < 0.05), suicide attempts (chi 2 = 4.51; df = 1; P < 0.05), and dysthymia (chi 2 = 8.85; df = 1; P < 0.01) than control girls. Sexually abused girls showed significantly lower basal (t = 2.1; df = 24; P < 0.05), and net oCRH stimulated (t = 2.2; df = 24; P < 0.05) ACTH levels and significan...
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Citations
Childhood Abuse and Neglect as Risk Factors for Central Adiposity: A Test of Association and Mediation Pathways
Aimee J Midei
- 22 Jan 2009
TL;DR: In this paper, the authors examined the association between childhood abuse/neglect and central adiposity and obesity in a sample of 311 women from the Pittsburgh site of the Study of Women's Health Across the Nation (SWAN).
Acquired Cytogenetic Changes in Adult Twins Discordant for a History of Childhood Sexual Abuse
Jenni Brumelle
- 01 Jan 2011
TL;DR: In this article, the latent biological effect of childhood sexual abuse (CSA) on adults by quantifying acquired cytogenetic changes and cortisol levels in identical twins who were discordant or concordant for a history of CSA was evaluated.
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Kai Marie McCormack
- 01 Dec 2003
TL;DR: The data suggest that abused infants received lower quality care from their mothers, and that this impacted their cortisol levels, which suggests that rhesus monkeys exposed to early adversity may exhibit outcomes similar to those of maltreated humans, and their neuroendocrine development may look similar to that of individuals with psychological disorders.
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