Journal Article10.1210/JCEM.78.2.8106608
Hypothalamic-pituitary-adrenal axis dysregulation in sexually abused girls.
M. D. De Bellis,George P. Chrousos,Lorah D. Dorn,L. Burke,K. Helmers,Mitchel A. Kling,Penelope K. Trickett,F. W. Putnam +7 more
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TL;DR: The hypothalamic-pituitary-adrenal axis was characterized of a self-selected sample of sexually abused and control girls recruited from a prospective longitudinal study to characterized the biological manifestations and sequelae of childhood sexual abuse.
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Abstract: Childhood sexual abuse is associated with an increased incidence of age-concurrent and adult psychopathology. Little is known, however, about the biological manifestations and sequelae of childhood sexual abuse. In this study, we characterized the hypothalamic-pituitary-adrenal axis of a self-selected sample of sexually abused and control girls recruited from a prospective longitudinal study. Plasma ACTH and total and free cortisol responses to ovine CRH (oCRH) stimulation were measured in 13 sexually abused and 13 control girls, aged 7-15 yr. Psychiatric profiles and 24-h urinary free cortisol (UFC) measures were also obtained. Sexually abused girls had a greater incidence of suicidal ideation (chi 2 = 4.51; df = 1; P < 0.05), suicide attempts (chi 2 = 4.51; df = 1; P < 0.05), and dysthymia (chi 2 = 8.85; df = 1; P < 0.01) than control girls. Sexually abused girls showed significantly lower basal (t = 2.1; df = 24; P < 0.05), and net oCRH stimulated (t = 2.2; df = 24; P < 0.05) ACTH levels and significan...
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References
Clinical and biochemical manifestations of depression. Relation to the neurobiology of stress (2)
TL;DR: Whereas psychopharmacologic intervention may be required to resolve an active episode of major depression and to prevent recurrences, psychotherapy may be equally important to lessen the burden of stress imposed by intense inner conflict and counterproductive defenses.
1K
Corticotropin releasing factor produces behavioural activation in rats
TL;DR: It is reported here that centrally injected synthetic CRF produces a dose-dependent locomotor activation in rats, suggesting that CRF may have an activating action in the central nervous system independent of its effects on the anterior pituitary gland.
771
Estimation of human body surface area from height and weight
E A Gehan,Stephen L. George +1 more
- 01 Aug 1970
TL;DR: A tubular member such as a cartridge which is filled with a material that, upon heating, changes its state from liquid to solid is flocked to enhance heat transfer from the Tubular member to hair rolled around the tubular members.
642
Impact of sexual and physical abuse on women's mental health.
TL;DR: Findings indicate that the deleterious effects of abuse can continue to contribute to psychiatric morbidity for many years.
637
Victims of violence and psychiatric illness.
TL;DR: The authors investigated the relationship between physical and sexual abuse and psychiatric illness by reconstructing the life experiences of 188 male and female psychiatric patients through an in-depth examination of psychiatric inpatient records.
567