Journal Article10.1210/JCEM.78.2.8106608
Hypothalamic-pituitary-adrenal axis dysregulation in sexually abused girls.
M. D. De Bellis,George P. Chrousos,Lorah D. Dorn,L. Burke,K. Helmers,Mitchel A. Kling,Penelope K. Trickett,F. W. Putnam +7 more
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TL;DR: The hypothalamic-pituitary-adrenal axis was characterized of a self-selected sample of sexually abused and control girls recruited from a prospective longitudinal study to characterized the biological manifestations and sequelae of childhood sexual abuse.
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Abstract: Childhood sexual abuse is associated with an increased incidence of age-concurrent and adult psychopathology. Little is known, however, about the biological manifestations and sequelae of childhood sexual abuse. In this study, we characterized the hypothalamic-pituitary-adrenal axis of a self-selected sample of sexually abused and control girls recruited from a prospective longitudinal study. Plasma ACTH and total and free cortisol responses to ovine CRH (oCRH) stimulation were measured in 13 sexually abused and 13 control girls, aged 7-15 yr. Psychiatric profiles and 24-h urinary free cortisol (UFC) measures were also obtained. Sexually abused girls had a greater incidence of suicidal ideation (chi 2 = 4.51; df = 1; P < 0.05), suicide attempts (chi 2 = 4.51; df = 1; P < 0.05), and dysthymia (chi 2 = 8.85; df = 1; P < 0.01) than control girls. Sexually abused girls showed significantly lower basal (t = 2.1; df = 24; P < 0.05), and net oCRH stimulated (t = 2.2; df = 24; P < 0.05) ACTH levels and significan...
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Citations
Associations between childhood trauma and emotion-modulated psychophysiological responses to startling sounds: a study of police cadets.
Nnamdi Pole,Thomas C. Neylan,Christian Otte,Thomas J. Metzler,Suzanne R. Best,Clare Henn-Haase,Charles R. Marmar +6 more
TL;DR: Results suggest that childhood trauma may lead to long-lasting alterations in emotional and psychophysiological reactivity even in the absence of current Axis I psychopathology.
68
Early-life origin of adult insomnia: does prenatal-early-life stress play a role?
TL;DR: In this article, early-life stress exposure was found to play an important role in predisposing to a vulnerability to hyperarousal reactions to negative life events in the adult contributing to the development of chronic insomnia.
67
Transgenerational effects of infantile adversity and enrichment in male and female rats.
TL;DR: The finding that enrichment, whether to the parent or offspring generation, can ameliorate the transgenerational impact of adversity, has novel implications for the malleability ofTransgenerational inheritance, and its individual, social, and therapeutic impact.
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Corticotropin-releasing hormone challenge in prepubertal major depression
Boris Birmaher,Boris Birmaher,Ronald E. Dahl,Ronald E. Dahl,James M. Perel,James M. Perel,Douglas E. Williamson,Douglas E. Williamson,Beverly Nelson,Beverly Nelson,Beverly Nelson,Stacy Stull,Stacy Stull,Stacy Stull,Joan Kaufman,Joan Kaufman,Joan Kaufman,G. Scott Waterman,G. Scott Waterman,G. Scott Waterman,Uma Rao,Uma Rao,Uma Rao,Nga H. Nguyen,Nga H. Nguyen,Nga H. Nguyen,Puig-Antich Joaquim,Puig-Antich Joaquim,Puig-Antich Joaquim,Neal D. Ryan,Neal D. Ryan,Neal D. Ryan +31 more
TL;DR: Overall, there were no significant differences between the MDD and the normal controls in baseline or post CRH stimulation values of either cortisol or ACTH, consistent with a broad literature suggesting that the HPA axis abnormalities occur less frequently in early-onset depression than reported in adult studies.
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Beyond posttraumatic stress disorder : object relations and reality testing disturbances in physically and sexually abused adolescents
TL;DR: Alienation and social incompetence, the two object relations disturbances not correlated with PTSD symptom severity, were associated with having experienced abuse at an early age and having been abused by a parent or stepparent (versus a nonparent).
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